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Table 3 NMR peak ratios measured on K562wt and K562adr spectra. PBS: incubation in PBS; PFA: incubation in PFA; Triton : incubation in PFA and triton X; Smase: incubation in PFA, triton X-100 and 0.5 units sphingomyelinase. Results are expressed as means of arbitrary units ± SD multiplied by ten.

From: Proton NMR visible mobile lipid signals in sensitive and multidrug-resistant K562 cells are modulated by rafts

 

K562wt

K562adr

Group

PBS (n = 4)

PFA (n = 7)

Triton (n = 7)

Smase (n = 4)

PBS (n = 4)

PFA (n = 7)

Triton (n = 8)

Smase (n = 5)

CH3/Ct

198 ± 21

231 ± 12

312 ± 42*

392 ± 105°

161 ± 19

192 ± 22

265 ± 62*

267 ± 42*

CH2/Ct

541 ± 52

611 ± 78

1060 ± 164*

1696 ± 441°

308 ± 93

386 ± 56

695 ± 141*

565 ± 167*

N(CH3)3/Ct

132 ± 6

141 ± 18

53 ± 10*

79 ± 17°

114 ± 12

132 ± 36

60 ± 15*

94 ± 39*

  1. Statistical analysis : * : P < 0.05 when compared with PBS-incubated cells,
  2. °: P < 0.05 when compared with Triton-treated cells,
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Cancer Cell International

ISSN: 1475-2867

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