Figure 5

The figure shows the stereotactic co-registration method of IR sodium tumor image, its counterpart histology and DNA ploidy map at different x- and y- co-ordinate locations shown as 1–5 and a-g for different areas. Notice the matched tumor delineated areas on three digitized images and corresponding features shown with arrows for high % apoptosis (A), high % EC volume (B), cyst (C), % viable cells and proliferation (D), % necrosis (E) in high power fields. The tumor IR sodium MR image appears hypointense for cyst and high EC regions and hyperintense for active proliferation while isointense for necrosis. On right panel, sodium signal intensities are shown for 100 mM SQ sodium phantom and 10 mM IR sodium phantom along with relative MRI signal intensities in the different tumor regions.