Figure 8

The sodium IR MRI signal intensities and calculated IR sodium concentrations are shown as histograms for pre-malignant tumor features shown in Figure 7. In left panel A, different intracellular sodium MRI signal intensities and concentrations indicated for [intraductal proliferation 11.5(2); ductal hyperplacia 8.8 (3); apoptosis with intraductal carcinoma 12.4* (6,13) and active proliferation 6.2* (2); ductal carcinoma 14.2* (17); cribriform ductal carcinoma 12.8* (7); ductal comedo carcinoma 12.2* (4)]; Malignant features [papillary carcinoma 13.5* (9,11); invasive cribriform carcinoma 12.8* (18); invasive comedo carcinoma 13.5* (22); tubular carcinoma 13.8*; adenoma 12.5* (2,8)]. Tumor different histology features under high power fields are shown in brackets correspond with histology regions in Figure 7. The panel B, in center represents the match of IC sodium concentrations with IC sodium MRI signal intensities. In different tumor regions, IC sodium MRI concentrations were calculated relative to the phantom MRI signal intensities shown as linear curve in Figure 2. In the right panel C, IC sodium concentrations and MRI signal intensities at different tumor premalignant or malignant locations represent the possibility of quick assessment of tumor characterization with possible staging.