Pre-drug treated@ Post-drug treated# | Sodium MRI signal intensityd | Histology (in HPF) | A.I. (KI-67) | P.I. (in HPF) | S-DNA (histogram) | ss-DNA mAb (density units) | |
---|---|---|---|---|---|---|---|
Tumor feature | IR | SQ | (CAS) | ||||
Control (n = 41) | 4.25 ± 1.0 | 5.27 ± 2.0 | - | - | - | - | - |
Sham (n = 40) | 4.30 ± 0.2 | 5.38 ± 1.0 |  |  |  |  |  |
Tumor area(mm2;n = 16)@ | 4.56 ± 0.30 | 4.67 ± 0.30 | 4.49 ± 0.2 | - | - | 3.6 ± 0.2 | 4.2 ± 0.2 |
Tumor area(mm2;n = 3)# | 4.60 ± 0.29 | 4.61 ± 0.26 | 4.42 ± 0.3 | - | - | 3.5 ± 0.3 | 4.3 ± 0.3 |
IC/EC space@ | 60–70 |  | 65–76 | - | - | - | - |
IC/EC space# | 80–95 |  | 60–70 | - | - | - | - |
Necrosis*(squares)@ | gray |  | 56 ± 32 | - | 270 | M-DNA | - |
Necrosis*(squares)# | bright |  | 50 ± 23 | - | 120 | M-DNA | - |
Viable**(squares)@ | dark |  | 65 ± 21 | - | - | - | - |
Viable**(squares)# | dark |  | 76 ± 11 | - | - | - | - |
Apoptosis***(nuclei)@ | bright |  | 40 ± 12 | 150 | - | S-DNA | 159 ± 12 |
Apoptosis***(nuclei)# | bright |  | 50 ± 13 | 160 | - | M or S-DNA | 129 ± 20 |
Cyst****(size in μm)@ | gray |  | 120 ± 29 | - | - | - | - |
Cyst****(size in μm)# | gray |  | 80 ± 22 | - | - | - | - |