Table 2 Comparison of tumor characteristics in different regions is shown in pre-drug treated tumor^@ and post-treated tumor^# by sodium MRI image intensity and histology, histo-immunology parameters as shown in Figures 5 and 6. By using eyepiece-micrometer square counter (100 squares per high power field), necrosis*(<25% cells in micrometer square), viable cells**(<60% cells in micrometer square) and apoptosis*** (20–40 apoptotic nuclei in HPF) and cyst space****(<100 μm) per HPF were premalignant histology characteristics. IC/EC space (% space in HPF), necrosis, viable cells are shown as number of micrometer squares with <25% necrosis area in HPF by histology. Apoptotic index (A.I.) and proliferation index (P.I.) are shown as average number of apoptotic nuclei per HPF and number of mitotic figures per HPF. S-DNA histogram area was measured by CAS 200 system in arbitrary units. Single strand-DNA mAb area was measured in digital images by Optimas 6.5 and ss-DNA mAb density was measured in arbitrary units of photomultiplier scanner.

From: Rapid in vivo Taxotere quantitative chemosensitivity response by 4.23 Tesla sodium MRI and histo-immunostaining features in N-Methyl-N-Nitrosourea induced breast tumors in rats