Table 4 Histological characteristics of MNU induced rat breast pre-treatment tumors under magnification × 400 microscopy equipped with micrometer. Different premalignancy and malignant characteristics and cytomorphology characteristics were co-registered with IR sodium signal intensities. Level of brightness is shown as + sign on MRI gray scale.
Sodium MRI signal Intensity | Histomorphology | Tumor characteristics | |
|---|---|---|---|
SQ Na MRI | IR Na MRI | Tumor features | Tumor stage |
| Â | Â | Â | Pre-malignant stage: |
isointense dark/gray | ++ + | Viable Active necrosis | Intraductal proliferation, ductal hyperplacia, apoptosis |
| Â | Â | Â | Malignant stage: |
gray | ++++ | apoptosis | Transformation stage |
+++ | bright/gray | apoptosis | Carcinoma (papillary; invasive comedo and cribriform) |
++++ | dark | Cyst | sarcoma, neoplasia |