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Table 4 Histological characteristics of MNU induced rat breast pre-treatment tumors under magnification × 400 microscopy equipped with micrometer. Different premalignancy and malignant characteristics and cytomorphology characteristics were co-registered with IR sodium signal intensities. Level of brightness is shown as + sign on MRI gray scale.

From: Rapid in vivo Taxotere quantitative chemosensitivity response by 4.23 Tesla sodium MRI and histo-immunostaining features in N-Methyl-N-Nitrosourea induced breast tumors in rats

Sodium MRI signal Intensity Histomorphology Tumor characteristics
SQ Na MRI IR Na MRI Tumor features Tumor stage
    Pre-malignant stage:
isointense dark/gray ++ + Viable Active necrosis Intraductal proliferation, ductal hyperplacia, apoptosis
    Malignant stage:
gray ++++ apoptosis Transformation stage
+++ bright/gray apoptosis Carcinoma (papillary; invasive comedo and cribriform)
++++ dark Cyst sarcoma, neoplasia