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Table 5 Different IC Na MRI signal intensities represent the matched locations of different tumor premalignant and malignant stages on tumor histology sites as shown in Figure 7 in different panels for: pre-malignant features [intraductal proliferation 11.5(2); ductal hyperplacia 8.8 (3); apoptosis with intraductal carcinoma 12.4* (6,13) and active proliferation 6.2* (2); ductal carcinoma 14.2* (17); cribriform ductal carcinoma 12.8* (7); ductal comedo carcinoma 12.2* (4)]; Malignant features [papillary carcinoma 13.5* (9,11); invasive cribriform carcinoma 12.8* (18); invasive comedo carcinoma 13.5*(22); tubular carcinoma 13.8*; adenoma 12.5* (2,8)]. The IC Na concentrations were measured by using IC Na MRI phantom standard graph as shown in Figure 2.

From: Rapid in vivo Taxotere quantitative chemosensitivity response by 4.23 Tesla sodium MRI and histo-immunostaining features in N-Methyl-N-Nitrosourea induced breast tumors in rats

Tumor feature IC Na MRI signal intensity IC Na concentration (mM)
intraductal proliferation 11.50 13.8
ductal hyperplacia 8.80 10.6
intraductal carcinoma 12.40 15.0
ductal carcinoma 14.20 17.0
cribriform ductal carcinoma 12.80 15.4
ductal comedo carcinoma 12.20 14.6
papillary carcinoma 13.50 16.2
invasive cribriform carcinoma 12.80 15.4
active proliferation 6.20 7.4
invasive comedo carcinoma 13.50 16.2
tubular carcinoma 13.80 16.6
adenoma 12.50 15.0
10 mM IC Na phantom 8.5 10.0
100 mM IC Na phantom 80.0 100.0