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Table 6 Comparison of delineated feature areas on intracellular sodium [Na]i images and histology digital images is shown at different levels for contiguous IR sodium MR slices (top row) and corresponding histology digital maps next to phantom (P). At bottom, each left bar represents histological area and each right bar represents delineated tumor area on both [Na]i image and histology digital images at different slice levels as shown in Table 5. Quantification of tumor area was done by Optimas 6.5 using sodium MRI and histology digital images. The tumor area was measured in mm2 in one representative tumor shown in Figure 8. Tumor area was measured and correlated in contiguous 6 histology sections with matched IR images (r2 = 0.3487) and scanned ss-DNA mAb digital images in mm2 (r2 = 0.3987). ss-DNA densities in arbitrary units were measured at different locations of the tumor digital images as shown in Figure 5.

From: Rapid in vivo Taxotere quantitative chemosensitivity response by 4.23 Tesla sodium MRI and histo-immunostaining features in N-Methyl-N-Nitrosourea induced breast tumors in rats

  Tumor Area Measurement_in images   
MRI slice Sodium MRI Histology ss-DNA mAb
(in mm2) (in mm2) (in mm2) (arbitrary units)
  (a) (b) (c)  
Slice 1 4.68 4.54 4.51 102.2
Slice 2 4.37 3.57 4.21 118.9
Slice 3 5.10 5.20 5.10 114.6
Slice 4 5.02 4.47 4.44 97.9
Slice 5 3.53 4.97 4.50 106.9
Slice 6 3.61 4.48 4.12 142.9