Table 1 Gene locus and tissue distribution of ABC transporters
Name | Alternate name | Gene locus | Tissue distribution |
|---|---|---|---|
MDR1 | ABCB1, P-GP | 7q36 [9] | Gut (apical membrane), liver (canalicular membrane), kindey (apical membrane of epithelial cells of proximal tubule), blood brain barrier (luminal membrane of endothelial cells), testis (endothelial cells of capillary), placenta (trophoblast) |
MRP1 | ABCC1 | 16p13.1 [6] | Many tissues (brain etc) |
MRP2 | ABCC2, cMOAT | 10q24 [10] | Liver, gut, kidney, placenta |
MRP3 | ABCC3 | 17q21.3 [11] | Liver, gut, adrenal cortex, placenta |
MRP4 | ABCC4 | 13q32 [11] | Many tissues |
MRP5 | ABCC5 | 3q27 [11] | Many tissues(brain etc) |
MRP6 | ABCC6 | 16p13.1 [12] | Liver, kidney |
MRP7 | ABCC10 | 6p12-21 [13] | Many tissues |
MRP8 | ABCC11 | 16q12.1 [14] | Breast, testes |
BCRP | ABCG2, MXR1, ABCP | 4q22 [15] | Placenta (syncytiotrophoblasts), intestine (epithelium), liver (canalicular membrane), breast (ducts and lobules), endometrium (vein and capillary but not artery), gut |