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Table 4 Comparison of chemosensitizing effects of flavonoids and verapamil against Pgp

From: ABC transporters as multidrug resistance mechanisms and the development of chemosensitizers for their reversal

Chemosensitizer IC50a(μM) CIc
(VCRb-) (VCR+)
5,7,3',4',5' – pentamethoxyflavone > 400 0.4 >1000
7,3',4' – trimethoxyflavone > 400 1.2 >333.3
3',4' – dimethoxyflavone 386 1.2 321.7
3,6,3',4' – tetramethoxyflavone > 400 1.9 >210.5
Verapamil 61 0.4 152.5
5,6,7,3',4' – pentamethoxyflavone > 400 3.2 >125
  1. Cytotoxic and chemosensitizing effects of chemosensitizers in the presence or absence of vincristine in Pgp-overexpressing AML-2/D100 cells.
  2. a, Drug concentrations with inhibit 50% growth of the cells.
  3. b, Vincristine (100 ng/ml)
  4. c, Chemosensitizing index = IC50 (VCR-)/IC50(VCR+)