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Figure 1 | Cancer Cell International

Figure 1

From: Mechanisms of genotoxin-induced transcription and hypermutation in p53

Figure 1

Linear regression analyses of the correlations between predicted and observed mutation frequency in p53. The mutations analyzed are the first two positions of codons 175, 245, 248, 249, 273, and 282. Mutation frequencies are correlated with: (a) MI, the base mutability index; (b) Percent unpaired, the fraction of total folds during transcription in which each mutable base is unpaired; and (c) -ΔG, the stability (kcal/mol) of the most stable secondary structure in which each base is unpaired. Data on the y-axis are obtained from the mfg computer program that simulates transcription [17].

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