Figure 2

Visual depictions of the frequencies and fates of G mutations due to lung cancers in p53. (a) In lung cancer mutations compared to all cancers, there is a decrease of 30.1% (orange) in G-to-A mutations, an increase of 25.2% (green) in G-to-T mutations, and an increase of 4.9% (blue) in G-to-C mutations. (b) The relative number or frequency of G mutations (gray), resulting from transcription, compared to the relative frequencies with which these Gs mutate to the other three bases, following the same color scheme as in (a). The number of cancers is equal to the number of mutable Gs. The thickness of each arrow is proportional to percent mutation frequencies, and the dual role of genotoxins is indicated. The data are derived from Tables 1-3.