Mechanisms of genotoxin-induced transcription and hypermutation in p53

Table 1 Mutations in lung compared to all cancers (including lung) in p53 codons 210–290

	A	C	G	T
Total number of all mutations in 240 nt (6662)	865	1875	3375	547
Percent of total	13.0%	28.1%	50.7%	8.2%
Number of lung mutations in 240 nt (875)	126	198	484	67
Percent of lung	14.4%	22.6%	55.3%	7.7%
Difference in total mutations compared to lung mutations	+1.4%	-5.5%	+4.6%	-0.5%

All point mutations in codons 210–290 were analyzed.
Table 1 shows the total number of all mutations (including lung) compared to lung mutations and the propensity of each of the four bases to mutate to any other base. This sequence is composed of 56 As, 66 Cs, 67 Gs, and 54 Ts. Mutations of G are shown in bold.

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