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Table 10 Mutations in lung compared to all cancers in hypermutable codons 248 and 273

From: Mechanisms of genotoxin-induced transcription and hypermutation in p53

  A C G T
Total number of mutations in 4 nt (1775) 0 728 1047 0
Percent of total 0 41.0% 59.0% 0
Number of lung mutations in 4 nt (187) 0 63 124 0
Percent of lung 0 33.7% 66.3% 0
Difference in total mutations compared to lung mutations 0 -7.3% +7.3% 0
  1. These hypermutable bases consist of the first two positions of codons 248 and 273.
  2. The composition of the bases analyzed is 2 Cs and 2Gs. Table 10 shows the total number of mutations (including lung) compared to lung mutations and the propensity of these mutable bases to mutate to any other base (with total mutations of G in bold).
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