Mechanisms of genotoxin-induced transcription and hypermutation in p53

Table 10 Mutations in lung compared to all cancers in hypermutable codons 248 and 273

	C	G
Total number of mutations in 4 nt (1775)	728	1047
Percent of total	41.0%	59.0%
Number of lung mutations in 4 nt (187)	63	124
Percent of lung	33.7%	66.3%
Difference in total mutations compared to lung mutations	-7.3%	+7.3%

These hypermutable bases consist of the first two positions of codons 248 and 273.
The composition of the bases analyzed is 2 Cs and 2Gs. Table 10 shows the total number of mutations (including lung) compared to lung mutations and the propensity of these mutable bases to mutate to any other base (with total mutations of G in bold).

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