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Table 11 Mutations of G to other bases in hypermutable codons 248 and 273

From: Mechanisms of genotoxin-induced transcription and hypermutation in p53

  A C T
Total G mutations including lung (1047) 863 31 153
Percent of total 82.4% 3.0% 14.6%
Lung G mutations (124) 46 9 69
Percent of lung 37.1% 7.3% 55.6%
Difference in total G mutations due to the presence of lung mutations -45.3% +4.3% +41.0%
  1. These hypermutable bases consist of the first two positions of codons 248 and 273.
  2. The composition of the bases analyzed is 2 Cs and 2Gs. Table 11 shows the ultimate fate of G mutations in all cancers due to lung mutations (with G-to-A and G-to-T in bold).
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