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Table 11 Mutations of G to other bases in hypermutable codons 248 and 273

From: Mechanisms of genotoxin-induced transcription and hypermutation in p53

 

A

C

T

Total G mutations including lung (1047)

863

31

153

Percent of total

82.4%

3.0%

14.6%

Lung G mutations (124)

46

9

69

Percent of lung

37.1%

7.3%

55.6%

Difference in total G mutations due to the presence of lung mutations

-45.3%

+4.3%

+41.0%

  1. These hypermutable bases consist of the first two positions of codons 248 and 273.
  2. The composition of the bases analyzed is 2 Cs and 2Gs. Table 11 shows the ultimate fate of G mutations in all cancers due to lung mutations (with G-to-A and G-to-T in bold).