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Table 12 Mutations of C to other bases in hypermutable codons 248 and 273

From: Mechanisms of genotoxin-induced transcription and hypermutation in p53

  A G T
Total C mutations including lung (728) 11 21 696
Percent of total 1.5% 2.9% 95.6%
Lung mutations (63) 3 2 58
Percent of lung 4.8% 3.2% 92.1%
Difference in total C mutations due to the presence of lung C mutations +3.3% +0.3% -3.5%
  1. These hypermutable bases consist of the first two positions of codons 248 and 273.
  2. The composition of the bases analyzed is 2 Cs and 2Gs. Table 12 shows the ultimate fate of C mutations in all cancers due to the presence of lung cancers.