Mechanisms of genotoxin-induced transcription and hypermutation in p53

Table 2 Mutations of G to other bases in p53 codons 210–290

	A	C	T
Total G mutations including lung (3375)	2082	351	942
Percent of total	61.7%	10.4%	27.9%
Lung G mutations (484)	153	74	257
Percent of lung	31.6%	15.3%	53.1%
Difference in total G mutations due to the presence of lung G mutations	-30.1%	+4.9%	+25.2%

All point mutations in codons 210–290 were analyzed.
Table 2 shows the ultimate fate of G mutations in all cancers due to lung cancers, with G-to-A and G-to-T mutations in bold.

ISSN: 1475-2867