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Table 7 Mutations in lung compared to all cancers in fifteen hypermutable bases of p53

From: Mechanisms of genotoxin-induced transcription and hypermutation in p53

  A C G T
Total number of all mutations in 15 nt (3292) 225 1195 1857 15
Percent of total 6.8% 36.3% 56.4% 0.5%
Number of lung mutations in 15 nt (407) 26 107 273 1
Percent of lung 6.4% 26.3% 67.1% 0.2%
Difference in total mutations compared to lung mutations -0.4% -10.0% +10.7% -0.3%
  1. These hypermutable bases consist of the first two positions of codons 213, 220, 245, 248, 273, and 282 and all positions in codon 249.
  2. The composition of the bases analyzed is 2 As, 4 Cs, 8Gs, and 1T. Table 7 shows the total number of all mutations (including lung) compared to lung mutations and the propensity of these mutable bases to mutate to any other base (with mutations of G in bold).