TY - JOUR AU - Jiang, Yan-Nian AU - Li, Yi-Hung AU - Ke, Meng-Wei AU - Tseng, Ting-Yu AU - Tang, Yueh-Bih AU - Huang, Mu-Chiou AU - Cheng, Winston Teng-Kuei AU - Ju, Yu-Ten PY - 2007 DA - 2007/03/02 TI - Caveolin-1 sensitizes rat pituitary adenoma GH3 cells to bromocriptine induced apoptosis JO - Cancer Cell International SP - 1 VL - 7 IS - 1 AB - Prolactinoma is the most frequent pituitary tumor in humans. The dopamine D2 receptor agonist bromocriptine has been widely used clinically to treat human breast tumor and prolactinoma through inhibition of hyperprolactinemia and induction of tumor cell apoptosis, respectively, but the molecular mechanism of bromocriptine induction of pituitary tumor apoptosis remains unclear. Caveolin-1 is a membrane-anchored protein enriched on caveolae, inverted flask-shaped invaginations on plasma membranes where signal transduction molecules are concentrated. Currently, caveolin-1 is thought to be a negative regulator of cellular proliferation and an enhancer of apoptosis by blocking signal transduction between cell surface membrane receptors and intracellular signaling protein cascades. Rat pituitary adenoma GH3 cells, which express endogenous caveolin-1, exhibit increased apoptosis and shrinkage after exposure to bromocriptine. Hence, the GH3 cell line is an ideal model for studying the molecular action of bromocriptine on prolactinoma. SN - 1475-2867 UR - https://doi.org/10.1186/1475-2867-7-1 DO - 10.1186/1475-2867-7-1 ID - Jiang2007 ER -