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Figure 4 | Cancer Cell International

Figure 4

From: Caveolin-1 sensitizes rat pituitary adenoma GH3 cells to bromocriptine induced apoptosis

Figure 4

Caveolin-1 induces GH3 apoptosis via caspase 8 activity. Caspase inhibitors (50 μM) were added to either pcDNA4-Caveolin-1 or pcDNA4-DsRed-N1 (negative control) transfected GH3 cells and the proportion of apoptotic cells quantified 48 hours after transfection by immunocytochemical and TUNEL assays. Data were expressed as mean ± standard deviation from 3 independent experiments (angular transformed for analysis, back-transformed for presentation). Abbreviations on the x-axis: General caspase inhibitor (Z-VAD-fmk); a negative control inhibitor (Z-FA-fmk); specific caspase inhibitors for caspase 3 (Z-DEVE-fmk), caspase 8 (Z-IETD-fmk) or caspase 9 (Z-LEHO-fmk).

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