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Table 1 Genes differentially expressed in CD133+/CD34+ cells after 1h-treatment with 10 nM estradiol. Only those genes and their corresponding functional classes found significantly associated with the estradiol treatment are shown (P-values = 0.001, according to the Fisher Exact Test for enrichment analysis). Expression data is given as fold change from control, with negative values indicating repression. Additional information on deregulation in cancer and functional evidence of role in tumorigenesis is provided based on in silico SAGE and literature datamining*, respectively.

From: Common molecular pathways involved in human CD133+/CD34+ progenitor cell expansion and cancer

ACCESSION No.

FOLD CHANGE

DEREGULATED IN CANCER

FUNCTION IN TUMORIGENESIS

DESCRIPTION

    

UP-REGULATED GENES

TRANSCRIPTION( P -value = 1.3E-17)

NM_003426

2,3

yes

ND

zinc finger protein 74 (Cos52)

AK024438

2.1

yes

ND

hypothetical protein FLJ38705

NM_005419

2.3

yes

yes

signal transducer and activator of transcription 2, 113 kDa

NM_032329

2.5

yes

yes

inhibitor of growth family, member 5

NM_005239

2.3

yes

yes

v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (ETS2)

NM_032433

2.1

yes

ND

zinc finger protein 333

AK024763

2.1

yes

ND

small nuclear RNA activating complex, polypeptide 5, 19 kDa

NM_006732

2.2

yes

yes

FBJ murine osteosarcoma viral oncogene homolog B (FOSB)

AK024514

2.6

yes

yes

suppressor of zeste 12 homolog (Drosophila)

NM_000901

2.6

yes

ND

nuclear receptor subfamily 3, group C, member 2

NM_000209

2.1

yes

yes

insulin promoter factor 1, homeodomain transcription factor

NM_003073

2.3

yes

yes

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1)

NM_022465

2.0

yes

ND

zinc finger protein, subfamily 1A, 4 (Eos)

NM_006509

2.0

yes

yes

v-rel avian reticuloendotheliosis viral oncogene homolog (RELB)

BC032246

2.1

yes

ND

zinc finger protein 44 (KOX 7)

AK021493

2.2

yes

ND

cAMP responsive element binding protein 5

AF052094

2.7

yes

ND

endothelial PAS domain protein 1

AK025453

2.0

yes

yes

prospero-related homeobox 1

BI861540

2.2

yes

ND

PBX/knotted 1 homeobox 2

NM_005384

2.7

yes

ND

nuclear factor, interleukin 3 regulated

NM_145165

2.2

yes

ND

churchill domain containing 1

NM_144690

2.2

no

ND

zinc finger protein 582

NM_006713

2.6

yes

ND

SUB1 homolog (S. cerevisiae)

PROTEIN MODIFICATION ( P -value = 1.44E-7)

AF038042

2.1

yes

yes

BRCA1 associated RING domain 1

NM_007218

2.2

yes

yes

ring finger protein 139

NM_024686

2.4

yes

ND

tubulin tyrosine ligase-like family, member 7

AB011116

2.2

yes

ND

mahogunin, ring finger 1

AF070538

2.5

yes

ND

tripartite motif-containing 3

NM_024787

2.9

yes

ND

ring finger protein 122

AF176705

2.2

yes

ND

F-box protein 10

NM_023079

2.0

yes

ND

Ubiquitin-conjugating enzyme E2Z (putative)

G-PROTEIN COUPLED RECEPTOR( P -value = 3.57E-8)

NM_002386

2.3

yes

ND

melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)

NM_002980

2.8

yes

ND

secretin receptor

AF303373

2.1

no

ND

olfactory receptor, family 4, subfamily D, member 2

NM_005314

2.4

yes

ND

gastrin-releasing peptide receptor

NM_030774

2.0

no

ND

olfactory receptor, family 51, subfamily E, member 2

NM_004248

2.2

no

ND

G protein-coupled receptor 10

M76676

2.3

yes

ND

G protein-coupled receptor 135

    

DOWN-REGULATED GENES

TRANSCRIPTION ( P -value = 2.44E-7)

NM_030381

-2.7

yes

yes

GLI-Kruppel family member GLI2

NM_005920

-2.2

yes

yes

MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)

AF146694

-4.4

yes

ND

PHD finger protein 7

NM_017831

-2.6

no

ND

ring finger protein 125

NM_003316

-2.0

yes

ND

tetratricopeptide repeat domain 3

NM_004234

-2.2

no

ND

zinc finger protein 235

U69127

-2.5

yes

ND

far upstream element (FUSE) binding protein 3

NM_002466

-3.1

yes

ND

v-myb myeloblastosis viral oncogene homolog (avian)-like 2 (MYBL2)

NM_001166

-2.1

yes

yes

baculoviral IAP repeat-containing 2

AA001334

-2.7

yes

ND

zinc fingers and homeoboxes 2

NM_016166

-2.2

yes

ND

protein inhibitor of activated STAT, 1

PROTEOLYSIS AND PEPTIDOLYSIS ( P -value = 5.75E-9)

NM_003343

-2.0

yes

ND

ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast)

NM_023038

-2.6

yes

ND

ADAM metallopeptidase domain 19

NM_005800

-2.5

yes

ND

Ubiquitin specific peptidase like 1

NM_032582

-3.6

yes

ND

ubiquitin specific protease 32

NM_001335

-2.2

yes

ND

cathepsin W (lymphopain)

NM_000930

-2.0

yes

ND

plasminogen activator, tissue

PROTEIN KINASE CK2 ACTIVITY( P -value = 2.1E-10)

NM_006482

-2.8

yes

ND

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2

AF086179

-2.0

yes

yes

cyclin-dependent kinase 6

NM_005406

-2.8

yes

yes

Rho-associated, coiled-coil containing protein kinase 1

D50683

-2.0

yes

yes

transforming growth factor, beta receptor II (70/80 kDa)

NM_003954

-2.5

no

ND

mitogen-activated protein kinase kinase kinase 14

NM_014326

-2.5

yes

ND

death-associated protein kinase 2

  1. Only those genes and their corresponding functional classes found significantly associated with the estradiol treatment are shown (P-values = 0.001, according to the Fisher Exact Test for enrichment analysis). Expression data is given as fold change from control, with negative values indicating repression. Additional information on deregulation in cancer and functional evidence of role in tumorigenesis is provided based on in silico SAGE and literature datamining*, respectively.
  2. * Literature data mining was performed in batch by the DAVID 2.1 tool. ND = function not determined at the time of analysis.