From: Common molecular pathways involved in human CD133+/CD34+ progenitor cell expansion and cancer
ACCESSION No. | FOLD CHANGE | DEREGULATED IN CANCER | FUNCTION IN TUMORIGENESIS | DESCRIPTION |
---|---|---|---|---|
 |  |  |  | UP-REGULATED GENES |
TRANSCRIPTION( P -value = 1.3E-17) | ||||
NM_003426 | 2,3 | yes | ND | zinc finger protein 74 (Cos52) |
AK024438 | 2.1 | yes | ND | hypothetical protein FLJ38705 |
NM_005419 | 2.3 | yes | yes | signal transducer and activator of transcription 2, 113 kDa |
NM_032329 | 2.5 | yes | yes | inhibitor of growth family, member 5 |
NM_005239 | 2.3 | yes | yes | v-ets erythroblastosis virus E26 oncogene homolog 2 (avian) (ETS2) |
NM_032433 | 2.1 | yes | ND | zinc finger protein 333 |
AK024763 | 2.1 | yes | ND | small nuclear RNA activating complex, polypeptide 5, 19 kDa |
NM_006732 | 2.2 | yes | yes | FBJ murine osteosarcoma viral oncogene homolog B (FOSB) |
AK024514 | 2.6 | yes | yes | suppressor of zeste 12 homolog (Drosophila) |
NM_000901 | 2.6 | yes | ND | nuclear receptor subfamily 3, group C, member 2 |
NM_000209 | 2.1 | yes | yes | insulin promoter factor 1, homeodomain transcription factor |
NM_003073 | 2.3 | yes | yes | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1) |
NM_022465 | 2.0 | yes | ND | zinc finger protein, subfamily 1A, 4 (Eos) |
NM_006509 | 2.0 | yes | yes | v-rel avian reticuloendotheliosis viral oncogene homolog (RELB) |
BC032246 | 2.1 | yes | ND | zinc finger protein 44 (KOX 7) |
AK021493 | 2.2 | yes | ND | cAMP responsive element binding protein 5 |
AF052094 | 2.7 | yes | ND | endothelial PAS domain protein 1 |
AK025453 | 2.0 | yes | yes | prospero-related homeobox 1 |
BI861540 | 2.2 | yes | ND | PBX/knotted 1 homeobox 2 |
NM_005384 | 2.7 | yes | ND | nuclear factor, interleukin 3 regulated |
NM_145165 | 2.2 | yes | ND | churchill domain containing 1 |
NM_144690 | 2.2 | no | ND | zinc finger protein 582 |
NM_006713 | 2.6 | yes | ND | SUB1 homolog (S. cerevisiae) |
PROTEIN MODIFICATION ( P -value = 1.44E-7) | ||||
AF038042 | 2.1 | yes | yes | BRCA1 associated RING domain 1 |
NM_007218 | 2.2 | yes | yes | ring finger protein 139 |
NM_024686 | 2.4 | yes | ND | tubulin tyrosine ligase-like family, member 7 |
AB011116 | 2.2 | yes | ND | mahogunin, ring finger 1 |
AF070538 | 2.5 | yes | ND | tripartite motif-containing 3 |
NM_024787 | 2.9 | yes | ND | ring finger protein 122 |
AF176705 | 2.2 | yes | ND | F-box protein 10 |
NM_023079 | 2.0 | yes | ND | Ubiquitin-conjugating enzyme E2Z (putative) |
G-PROTEIN COUPLED RECEPTOR( P -value = 3.57E-8) | ||||
NM_002386 | 2.3 | yes | ND | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
NM_002980 | 2.8 | yes | ND | secretin receptor |
AF303373 | 2.1 | no | ND | olfactory receptor, family 4, subfamily D, member 2 |
NM_005314 | 2.4 | yes | ND | gastrin-releasing peptide receptor |
NM_030774 | 2.0 | no | ND | olfactory receptor, family 51, subfamily E, member 2 |
NM_004248 | 2.2 | no | ND | G protein-coupled receptor 10 |
M76676 | 2.3 | yes | ND | G protein-coupled receptor 135 |
 |  |  |  | DOWN-REGULATED GENES |
TRANSCRIPTION ( P -value = 2.44E-7) | ||||
NM_030381 | -2.7 | yes | yes | GLI-Kruppel family member GLI2 |
NM_005920 | -2.2 | yes | yes | MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D) |
AF146694 | -4.4 | yes | ND | PHD finger protein 7 |
NM_017831 | -2.6 | no | ND | ring finger protein 125 |
NM_003316 | -2.0 | yes | ND | tetratricopeptide repeat domain 3 |
NM_004234 | -2.2 | no | ND | zinc finger protein 235 |
U69127 | -2.5 | yes | ND | far upstream element (FUSE) binding protein 3 |
NM_002466 | -3.1 | yes | ND | v-myb myeloblastosis viral oncogene homolog (avian)-like 2 (MYBL2) |
NM_001166 | -2.1 | yes | yes | baculoviral IAP repeat-containing 2 |
AA001334 | -2.7 | yes | ND | zinc fingers and homeoboxes 2 |
NM_016166 | -2.2 | yes | ND | protein inhibitor of activated STAT, 1 |
PROTEOLYSIS AND PEPTIDOLYSIS ( P -value = 5.75E-9) | ||||
NM_003343 | -2.0 | yes | ND | ubiquitin-conjugating enzyme E2G 2 (UBC7 homolog, yeast) |
NM_023038 | -2.6 | yes | ND | ADAM metallopeptidase domain 19 |
NM_005800 | -2.5 | yes | ND | Ubiquitin specific peptidase like 1 |
NM_032582 | -3.6 | yes | ND | ubiquitin specific protease 32 |
NM_001335 | -2.2 | yes | ND | cathepsin W (lymphopain) |
NM_000930 | -2.0 | yes | ND | plasminogen activator, tissue |
PROTEIN KINASE CK2 ACTIVITY( P -value = 2.1E-10) | ||||
NM_006482 | -2.8 | yes | ND | dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2 |
AF086179 | -2.0 | yes | yes | cyclin-dependent kinase 6 |
NM_005406 | -2.8 | yes | yes | Rho-associated, coiled-coil containing protein kinase 1 |
D50683 | -2.0 | yes | yes | transforming growth factor, beta receptor II (70/80 kDa) |
NM_003954 | -2.5 | no | ND | mitogen-activated protein kinase kinase kinase 14 |
NM_014326 | -2.5 | yes | ND | death-associated protein kinase 2 |