Table 2 Regulatory signal transduction pathways and corresponding gene members found differentially expressed during expansion of CD133+/CD34+ cells.
From: Common molecular pathways involved in human CD133+/CD34+ progenitor cell expansion and cancer
Signaling Pathway | Control vs. GF | GF vs. E2 | ||
|---|---|---|---|---|
Up-regulated | Down-regulated | Up-regulated | Down-regulated | |
Calcium | GNAQ, GSD VI | PDGFB, ADRA1B, ERBA1, CACNA1I, PLCD3, PTK2B | CACNA1G, CACNA1D, ADORA2A, GRPR | ADCY3, CACNA1I, CACNA1H |
Hedgehog | - | - | - | GLI2 |
Insulin | GSD VI | IRS4 | PRKAG3 | - |
Jak-STAT | PIK3C2B, IL2R, IL5RA | CNTF, IL2RG, IFNGR2, IL23A | STAT2, CTNF | PIAS1, CTF1 |
MAPK | - | PDGFB, MAPK13, JUN, MEF2C, FGF6 | RPS6KA1, PLA2G10 | MAPKAPK3, ARRB1, FLNC, MAP3K14, TGFBR2 |
NF-Kappa B | - | - | - | BCL10, IRAK2 |
Notch | RBPSUH | - | - | - |
Phosphatidyl inositol | PIK3C2B | PLCD3 | CDS1, DGKE, SYNJ1 | CSNK1G2 |
TGF-Beta | - | INHBA, SMAD7 | E2F4 | ROCK1, TGFBR2 |
Wnt | - | DKK4 | - | - |