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Table 2 Published clinical trials with various in vitro and in vivo stem cell purging techniques.

From: Role of stem cells in cancer therapy and cancer stem cells: a review

Authors In Vivo/In Vitro Type of cancer(cells) Purging technique Conclusion
Barbui et al [120] IV & IT Multiple myeloma Two step negative selection procedure with combination of monoclonal antibodies Safe procedure of purging stem cells. Higher event free survival rate
Stewart et al [121] IT Multiple myeloma CEPRATE SC System – continuous flow immunoadsorption technique No advantage of purging of stem cells
Vescio et al. [122] IT Multiple myeloma CEPRATE SC System – continuous flow immunoadsorption technique Significantly reduce tumour cell contamination and provides safe and rapid haematological recovery
Shpall et al [123] IV Breast cancer WR-2721 (amifostine) to 4-hydroperoxycyclophosphamide (4-HC) Reduced time to engraftment
Huang et al [124] IT Breast cancer Dielectrophoretic field-flow-fractionation (DEP-FFF) Efficient separation was observed in 12 minutes with purity of > 99.2%
Borbolla-Escoboza et al [125] IT B cell lymphoma Rituximab Rituximab can be used in stem cell purging
Craiu et al [126]. IT Multiple myeloma Pulsed electric fields Promising technology for rapid stem cell purging
Wierenga et al [127] IT Acute myeloid leukaemia Hyperthermia Promising method for stem cell purging
  1. Keys: IT – in vitro, IV – in vivo.