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Table 1 Description and role of angiogenesis-related factors.

From: Comparison of angiogenesis-related factor expression in primary tumor cultures under normal and hypoxic growth conditions

Angiogenesis-Related Factor Role in Angiogenesis
Vascular Endothelial Growth Factor/Vascular Permeability Factor
Signalling protein for angiogenesis that works by binding, dimerizing, and phosphorylating external tyrosine kinase receptors. Can be induced by hypoxia through the release of Hypoxia Inducible Factor (HIF) [4, 6, 8, 10, 13].
Basic Fibroblast Growth Factor
Stimulates production of basement membranes via formation of extracellular matrix. Aids in angiogenesis in tumors by mediating VEGF production [6, 11, 14].
A chemokine that regulates angiogenesis by promoting survival of endothelial cells, stimulating matrix metalloproteinases, and increasing endothelial permeability [15, 16].
Epidermal Growth Factor
Factor commonly expressed in carcinomas involved in tumor growth, proliferation, and differentiation by stimulation of intrinsic protein-tyrosine kinase activity, resulting in DNA synthesis. Also, induces VEGF, IL-8, and bFGF release by tumor cells [9, 19].
Fms-related Tyrosine Kinase
(Flt-3 Ligand)
Cytokine that assists in proliferation and maturation of hematopoietic progenitor cells [20].
Platelet-derived Growth Factors
Mitogenic factors for fibroblasts, smooth muscle, and connective tissue that can be induced by VEGF and bFGF. Induce endothelial cell survival by recruiting stromal cells for VEGF production [9, 17].
Interferon-gamma-inducible Protein 10
Inhibits tumor growth by regulating lymphocyte chemotaxis and inhibiting endothelial cell growth. Down-regulation correlated with poor prognosis. Reverse-correlated with VEGF [21].
Transforming Growth Factors
Cytokines that control several biological processes including cell growth, proliferation, differentiation, and apoptosis. Pathological conditions such as cancer are can be linked to modifications of these growth factors [18].