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Table 4 Univariate and multivariate Cox regression analyses of PSA relapse.

From: Ebp1 expression in benign and malignant prostate

  Univariate analyses Multivariate analyses
   Base model Base model + CyclinD1+/ErbB3+(T) Base model + Ebp1+/CyclinD1-(T)
  Hazard ratio (95% CI); p Hazard ratio (95% CI); p Hazard ratio (95%CI); p Hazard ratio (95%CI); p
Gleason < 7 vs Gleason 7 1.67 0.99 0.96 1.36
  (0.78–3.57); (0.45–2.19); (0.43–2.17); (0.58–3.20);
  p = 0.186 p = 0.977 p = 0.924 p = 0.484
Gleason < 7 vs Gleason > 7 2.80 4.21 5.75 6.80
  (1.15–6.81); (1.65–10.75): (2.14–15.44); (2.40–19.30):
  p = 0.023 p = 0.030 p < 0.001 p < 0.001
Pre-Op PSA 1.03 .. .. ..
  (0.99–1.07); .. .. ..
  p = 0.198 .. .. ..
Surgical Margins 5.97 8.06 9.91 12.06
  (2.68–13.3); (3.32–19.55); (3.96–24.81); (4.48–32.49);
  p < 0.001 p < 0.001 p < 0.001 p < 0.001
P-Stage 5.15 .. .. ..
  (2.49–10.63); .. .. ..
  p < 0.001 .. .. ..
Molecular Marker .. .. 0.44 4.79
  .. .. (0.20–0.94); (1.73–13.26);
  .. .. p = 0.034 p = 0.003
Model P value .. p < 0.001 p < 0.001 p < 0.001
  1. Correlation between PSA relapse and the clinico-pathological parameters using univariate Cox regression analyses. Multi-variate Cox regression analysis of the base models and the base model + molecular marker.
  2. * Multi-Variate COX regression was perform under the Forward Wald model
  3. Normal Adjacent Tissues (NA): Tumor Tissues (T)