Figure 2
From: Lack of c-kit receptor promotes mammary tumors in N-nitrosomethylurea-treated Ws/Ws rats
Carcinogen-treated Ws/Ws rats developed mammary carcinomas. Panel A: whole mounts of mammary glands obtained from NMU-treated wild type and Ws/Ws rats. Only the mutant rats developed tumors while the microscopic lesions observed in the wild type mammary glands were benign lesions. Panel B: Histological sections of the region of interest outlined (yellow lines) in the whole mounts. The wild type rats showed large dilated ducts containing secretion (asterisks) whereas the Ws/Ws developed frank carcinomas. Sections were stained with hematoxylin and eosin. LN: lymph nodes. Ws/Ws: c-kit null rats. Scale bars: Panel A: 3.2 cm; Panel B: 100 μm and 50 μm.