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Figure 4 | Cancer Cell International

Figure 4

From: A novel and generalizable organotypic slice platform to evaluate stem cell potential for targeting pediatric brain tumors

Figure 4

Model of SDF-1-mediated signal transduction for targeting of stem cells toward brain tumor. Brain tumors release SDF-1 gradient into the tumor microenvironment. Binding SDF-1 to its receptor expressed in stem cells triggers the signal transduction pathways that lead to cytoskeletons reorganization, which drives stem cell migration toward brain tumor microenvironment. CXCR-4: chemokine (C-X-C motif) receptor 4, a.k.a., SDF-1 receptor or CD184; SDF-1: stromal cell-derived factor-1 (chemokine), a.k.a., CXCL12 (see [37]).

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Cancer Cell International

ISSN: 1475-2867

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