TY - JOUR AU - Flis, Sylwia AU - Gnyszka, Agnieszka AU - Misiewicz-Krzemińska, Irena AU - Spławiński, Jacek PY - 2009 DA - 2009/04/27 TI - Decytabine enhances cytotoxicity induced by oxaliplatin and 5-fluorouracil in the colorectal cancer cell line Colo-205 JO - Cancer Cell International SP - 10 VL - 9 IS - 1 AB - DNA methylation is an epigenetic phenomenon known to play an important role in the development of cancers, including colorectal cancer (CRC). Aberrant methylation of promoter regions of genes is potentially reversible, and if methylation is important for cancer survival, demethylation should do the opposite. To test this we have addressed the hypothesis that DNA methyltransferase inhibitors (DNMTi), decytabine and zebularine, potentiate inhibitory effects of classical anti-CRC cytostatics, oxaliplatin and 5-fluorouracil (5-FU), on survival of CRC cells in vitro. SN - 1475-2867 UR - https://doi.org/10.1186/1475-2867-9-10 DO - 10.1186/1475-2867-9-10 ID - Flis2009 ER -