Figure 4

A, B; HeLa cells were infected with live BCG after 1 hour and showed BCG(↑), residual body(RB) and lysosome(L) in the cytoplasm. Different stages of the lysosomal activity were induced by internalized BCG. C, D; HeLa cells were co-cultured with dead BCG(↑) which were also internalized after 1 hour and showed the lysosome and vacuole. E, F; HeLa cells co-cultured with live BCG after four days. HeLa cell showed lack of cell membrane(↑CM), lost of cytoplasm(↑CP), nuclear degeneration(N) and BCG(↑). The shape of BCG was keeping in the HeLa cell.