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Figure 1 | Cancer Cell International

Figure 1

From: A reason why the ERBB2 gene is amplified and not mutated in breast cancer

Figure 1

Schematic representation of the repression/amplification model in mammary epithelial cells. In these cells ERBB2 expression is regulated. A crosstalk between ER and ERBB2 pathways is an important feature of these cells. ERBB2 is normally expressed at low level in ER-negative cells (A). In ER-positive cells, ERBB2 expression is quenched by ER-induced transcriptional repressors (B). In ERBB2-positive tumors, amplification titrates out the repressors and allows overexpression of ERBB2; this may in turn shut down ER expression (C).

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