TY - JOUR AU - Wheatley, D. N. PY - 2004 DA - 2004// TI - Controlling cancer by restricting arginine availability – arginine-catabolizing enzymes as anticancer agents JO - Anticancer Drugs VL - 5 UR - https://doi.org/10.1097/00001813-200410000-00002 DO - 10.1097/00001813-200410000-00002 ID - Wheatley2004 ER - TY - JOUR AU - Wheatley, D. N. AU - Campbell, E. AU - Lai, P. B. S. AU - Cheng, P. N. M. PY - 2005 DA - 2005// TI - A rational approach to the systemic treatment of cancer involving medium-term depletion of arginine JO - Gene Ther Mol Biol VL - 9 ID - Wheatley2005 ER - TY - JOUR AU - Cheng, P. N. AU - Leung, Y. C. AU - Lo, W. H. AU - Tsui, S. M. AU - Lam, K. C. PY - 2005 DA - 2005// TI - Remission of hepatocellular carcinoma with arginine depletion induced by systemic release of endogenous hepatic arginase due to transhepatic arterial embolisation, augmented by high-dose insulin: arginase as a potential drug candidate for hepatocellular carcinoma JO - Cancer Lett VL - 224 UR - https://doi.org/10.1016/j.canlet.2004.10.050 DO - 10.1016/j.canlet.2004.10.050 ID - Cheng2005 ER - TY - JOUR AU - Cheng, P. N. AU - Lam, T. L. AU - Lam, W. M. AU - Tsui, S. M. AU - Cheng, A. W. AU - Lo, W. H. AU - Leung, Y. C. PY - 2007 DA - 2007// TI - Pegylated recombinant human arginase (rhArg1-peg5,000 mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion JO - Cancer Res VL - 67 UR - https://doi.org/10.1158/0008-5472.CAN-06-1945 DO - 10.1158/0008-5472.CAN-06-1945 ID - Cheng2007 ER - TY - JOUR AU - Cheng, P. AU - Wheatley, D. N. PY - 2008 DA - 2008// TI - Arginine deprivation addresses the Achilles Heel of Cancer: urea cycle deficiencies in melanoma, HCC and other cancers JO - Oncology News VL - 2 ID - Cheng2008 ER - TY - JOUR AU - Takaku, H. AU - Takase, M. AU - Abe, S. AU - Hayashi, H. AU - Miyazaki, K. PY - 1992 DA - 1992// TI - In vivo anti-tumor activity of arginine deiminase purified from Mycoplasma arginini JO - Int J Cancer VL - 51 UR - https://doi.org/10.1002/ijc.2910510213 DO - 10.1002/ijc.2910510213 ID - Takaku1992 ER - TY - JOUR AU - Ensor, C. M. AU - Holtsberg, F. W. AU - Bomalaski, J. S. AU - Clark, M. A. PY - 2002 DA - 2002// TI - Pegylated arginine deiminase (ADI-SS PEG20,000 mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo JO - Cancer Res VL - 62 ID - Ensor2002 ER - TY - JOUR AU - Broome, J. D. PY - 1968 DA - 1968// TI - Studies on the mechanism of tumor inhibition by L-asparaginase. Effects of the enzyme on asparagine levels in the blood, normal tissues, and 6C3HEB lymphomas of mice: differences in asparagine formation and utilisation in asparaginase-sensitive and -resistant lymphoma cells JO - J Exp Med VL - 127 UR - https://doi.org/10.1084/jem.127.6.1055 DO - 10.1084/jem.127.6.1055 ID - Broome1968 ER - TY - JOUR AU - Sun, X. AU - Yang, Z. AU - Li, S. AU - Tan, Y. AU - Zhang, N. AU - Wang, X. AU - Yagi, S. AU - Yoshioka, T. AU - Takimoto, A. AU - Mitsushima, K. AU - Suginaka, A. AU - Frenkel, E. P. AU - Hoffman, R. M. PY - 2003 DA - 2003// TI - In vivo efficacy of recombinant methioninase is enhanced by the combination of polyethylene glycol conjugation and pyridoxal 5'-phosphate supplementation JO - Cancer Res VL - 63 ID - Sun2003 ER - TY - JOUR AU - Ash, D. E. PY - 2004 DA - 2004// TI - Structure and function of arginases JO - J Nutr VL - 134 ID - Ash2004 ER - TY - CHAP AU - Cheng, N. M. AU - Leung, Y. C. AU - Lo, W. H. PY - 2005 DA - 2005// BT - US Patent no. 20050244398 ID - Cheng2005 ER - TY - JOUR AU - Ikemoto, M. AU - Tabata, M. AU - Miyake, T. AU - Kono, T. AU - Mori, M. AU - Totani, M. AU - Murachi, T. PY - 1990 DA - 1990// TI - Expression of human liver arginase in Escherichia coli. Purification and properties of the product JO - Biochem J VL - 270 UR - https://doi.org/10.1042/bj2700697 DO - 10.1042/bj2700697 ID - Ikemoto1990 ER - TY - JOUR AU - Roberts, M. J. AU - Harris, J. M. PY - 1998 DA - 1998// TI - Attachment of degradable poly(ethylene glycol) to proteins has the potential to increase therapeutic efficacy JO - J Pharm Sci VL - 87 UR - https://doi.org/10.1021/js9800634 DO - 10.1021/js9800634 ID - Roberts1998 ER - TY - JOUR AU - Harris, J. M. AU - Martin, N. E. AU - Modi, M. PY - 2001 DA - 2001// TI - Pegylation: a novel process for modifying pharmacokinetics JO - Clin Pharmacokinet VL - 40 UR - https://doi.org/10.2165/00003088-200140070-00005 DO - 10.2165/00003088-200140070-00005 ID - Harris2001 ER - TY - JOUR AU - Harris, J. M. AU - Chess, R. B. PY - 2003 DA - 2003// TI - Effect of pegylation on pharmaceuticals JO - Nat Rev Drug Discov VL - 2 UR - https://doi.org/10.1038/nrd1033 DO - 10.1038/nrd1033 ID - Harris2003 ER - TY - JOUR AU - Roberts, M. J. AU - Bentley, M. D. AU - Harris, J. M. PY - 2002 DA - 2002// TI - Chemistry for peptide and protein PEGylation JO - Adv Drug Deliv Rev VL - 54 UR - https://doi.org/10.1016/S0169-409X(02)00022-4 DO - 10.1016/S0169-409X(02)00022-4 ID - Roberts2002 ER - TY - JOUR AU - Goodson, R. J. AU - Katre, N. V. PY - 1990 DA - 1990// TI - Site-directed pegylation of recombinant interleukin-2 at its glycosylation site JO - Biotechnology (N Y) VL - 8 UR - https://doi.org/10.1038/nbt0490-343 DO - 10.1038/nbt0490-343 ID - Goodson1990 ER - TY - JOUR AU - Baker, D. E. PY - 2001 DA - 2001// TI - Pegylated interferons JO - Rev Gastroenterol Disord VL - 1 ID - Baker2001 ER - TY - JOUR AU - Savoca, K. V. AU - Davis, F. F. AU - van Es, T. AU - McCoy, J. R. AU - Palczuk, N. C. PY - 1984 DA - 1984// TI - Cancer therapy with chemically modified enzymes. II. The therapeutic effectiveness of arginase, and arginase modified by the covalent attachment of polyethylene glycol, on the taper liver tumor and the L5178Y murine leukemia JO - Cancer Biochem Biophys VL - 7 ID - Savoca1984 ER - TY - JOUR AU - Ikemoto, M. AU - Tabata, M. AU - Murachi, T. AU - Totani, M. PY - 1989 DA - 1989// TI - Purification and properties of human erythrocyte arginase JO - Ann Clin Biochem VL - 26 UR - https://doi.org/10.1177/000456328902600616 DO - 10.1177/000456328902600616 ID - Ikemoto1989 ER - TY - JOUR AU - Holtsberg, F. W. AU - Ensor, C. M. AU - Steiner, M. R. AU - Bomalaski, J. S. AU - Clark, M. A. PY - 2002 DA - 2002// TI - Poly(ethylene glycol) (PEG) conjugated arginine deiminase: effects of PEG formulations on its pharmacological properties JO - J Control Release VL - 80 UR - https://doi.org/10.1016/S0168-3659(02)00042-1 DO - 10.1016/S0168-3659(02)00042-1 ID - Holtsberg2002 ER - TY - JOUR AU - Ascierto, P. A. AU - Scala, S. AU - Castello, G. AU - Daponte, A. AU - Simeone, E. AU - Ottaiano, A. AU - Beneduce, G. AU - De Rosa, V. AU - Izzo, F. AU - Melucci, M. T. AU - Ensor, C. M. AU - Prestayko, A. W. AU - Holtsberg, F. W. AU - Bomalaski, J. S. AU - Clark, M. A. AU - Savaraj, N. AU - Feun, L. G. AU - Logan, T. F. PY - 2005 DA - 2005// TI - Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies JO - J Clin Oncol VL - 23 UR - https://doi.org/10.1200/JCO.2005.02.0933 DO - 10.1200/JCO.2005.02.0933 ID - Ascierto2005 ER - TY - JOUR AU - Goffin, V. AU - Touraine, P. PY - 2004 DA - 2004// TI - Pegvisomant Pfizer/Sensus JO - Curr Opin Investig Drugs VL - 5 ID - Goffin2004 ER - TY - JOUR AU - Carvajal, N. AU - Salas, M. AU - Lopez, V. AU - Uribe, E. AU - Herrera, P. AU - Cerpa, J. AU - Fuentes, M. PY - 1999 DA - 1999// TI - Manganese-dependent inhibition of human liver arginase by borate JO - J Inorg Biochem VL - 77 UR - https://doi.org/10.1016/S0162-0134(99)00187-7 DO - 10.1016/S0162-0134(99)00187-7 ID - Carvajal1999 ER - TY - JOUR AU - Savoca, K. V. AU - Abuchowski, A. AU - van Es, T. AU - Davis, F. F. AU - Palczuk, N. C. PY - 1979 DA - 1979// TI - Preparation of a non-immunogenic arginase by the covalent attachment of polyethylene glycol JO - Biochim Biophys Acta VL - 578 UR - https://doi.org/10.1016/0005-2795(79)90111-9 DO - 10.1016/0005-2795(79)90111-9 ID - Savoca1979 ER - TY - JOUR AU - Bowen, S. AU - Tare, N. AU - Inoue, T. AU - Yamasaki, M. AU - Okabe, M. AU - Horii, I. AU - Eliason, J. F. PY - 1999 DA - 1999// TI - Relationship between molecular mass and duration of activity of polyethylene glycol conjugated granulocyte colony-stimulating factor mutein JO - Exp Hematol VL - 27 UR - https://doi.org/10.1016/S0301-472X(98)00051-4 DO - 10.1016/S0301-472X(98)00051-4 ID - Bowen1999 ER - TY - JOUR AU - Kamada, H. AU - Tsutsumi, Y. AU - Yamamoto, Y. AU - Kihira, T. AU - Kaneda, Y. AU - Mu, Y. AU - Kodaira, H. AU - Tsunoda, S. I. AU - Nakagawa, S. AU - Mayumi, T. PY - 2000 DA - 2000// TI - Antitumor activity of tumor necrosis factor-alpha conjugated with polyvinylpyrrolidone on solid tumors in mice JO - Cancer Res VL - 60 ID - Kamada2000 ER - TY - JOUR AU - Gong, H. AU - Zolzer, F. AU - von Recklinghausen, G. AU - Havers, W. AU - Schweigerer, L. PY - 2000 DA - 2000// TI - Arginine deiminase inhibits proliferation of human leukemia cells more potently than asparaginase by inducing cell cycle arrest and apoptosis JO - Leukemia VL - 14 UR - https://doi.org/10.1038/sj.leu.2401763 DO - 10.1038/sj.leu.2401763 ID - Gong2000 ER - TY - JOUR AU - Philip, R. AU - Campbell, E. AU - Wheatley, D. N. PY - 2003 DA - 2003// TI - Arginine deprivation, growth inhibition and tumour cell death: 2. Enzymatic degradation of arginine in normal and malignant cell cultures JO - Br J Cancer. 2003 Feb 24;88(4):613-23 VL - 88 ID - Philip2003 ER - TY - JOUR AU - Izzo, F. AU - Marra, P. AU - Beneduce, G. AU - Castello, G. AU - Vallone, P. AU - De Rosa, V. AU - Cremona, F. AU - Ensor, C. M. AU - Holtsberg, F. W. AU - Bomalaski, J. S. AU - Clark, M. A. AU - Ng, C. AU - Curley, S. A. PY - 2004 DA - 2004// TI - Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: results from phase I/II studies JO - J Clin Oncol VL - 22 UR - https://doi.org/10.1200/JCO.2004.11.120 DO - 10.1200/JCO.2004.11.120 ID - Izzo2004 ER - TY - JOUR AU - Sreerama, N. AU - Venyaminov, S. Y. AU - Woody, R. W. PY - 2000 DA - 2000// TI - Estimation of protein secondary structure from circular dichroism spectra: inclusion of denatured proteins with native proteins in the analysis JO - Anal Biochem VL - 287 UR - https://doi.org/10.1006/abio.2000.4879 DO - 10.1006/abio.2000.4879 ID - Sreerama2000 ER -