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Table 3 Hematological values, clinical biochemical findings, and organ weights in SD rats after weekly injection of rhArg1-peg5,000 mw for 4 weeks.

From: Pegylated derivatives of recombinant human arginase (rhArg1) for sustained in vivo activity in cancer therapy: preparation, characterization and analysis of their pharmacodynamics in vivo and in vitro and action upon hepatocellular carcinoma cell (HCC)

Parameters Control 15,000 U/kg 50,000 U/kg
Hematological values
RBC (× 1012/l) 8.25 ± 0.87 8.91 ± 0.90 8.20 ± 0.89
WBC (× 109/l) 5.27 ± 1.14 5.68 ± 1.08 4.02 ± 0.71*
Hb (g/l) 136.33 ± 17.25 134.50 ± 6.83 122.33 ± 6.80
MCH (pg) 16.50 ± 1.05 15.23 ± 1.67 15.00 ± 1.12*
MCHC (g/l) 342.00 ± 13.31 287.17 ± 35.82** 305.17 ± 19.26**
PLT (× 109/l) 742.50 ± 156.23 663.00 ± 121.51 545.83 ± 113.26*
HCT (%) 0.399 ± 0.05 0.474 ± 0.06* 0.403 ± 0.039
MCV (fl) 48.33 ± 2.25 53.18 ± 4.03* 49.17 ± 0.96
Clinical biochemical findings
ALT (nmol/l) 818.50 ± 69.16 796.83 ± 110.52 733.48 ± 118.66
CK (μmol/l) 112.60 ± 37.41 88.30 ± 27.17 88.14 ± 24.33
CH (mmol/l) 3.219 ± 0.51 2.500 ± 0.6** 2.879 ± 0.639
AST (nmol/l) 2883.90 ± 602.99 2622.20 ± 420.55 2300.46 ± 512.72
ALB (g/l) 42.60 ± 8.38 40.10 ± 18.83 35.86 ± 5.46
TP (g/l) 86.70 ± 12.49 76.20 ± 10.25 84.86 ± 15.08
BUN (mmol/l) 7.919 ± 3.267 9.305 ± 1.200 9.801 ± 0.815
TG (mmol/l) 3.129 ± 1.087 2.672 ± 1.175 2.832 ± 0.112
Organ weights (g)
Brain 0.380 ± 0.063 0.345 ± 0.050 0.324 ± 0.031*
Gland 0.071 ± 0.026 0.080 ± 0.037 0.074 ± 0.023
Heart 0.184 ± 0.021 0.180 ± 0.031 0.195 ± 0.020
Lung 0.237 ± 0.040 0.216 ± 0.051 0.233 ± 0.038
  1. Notes: All values are expressed as mean ± standard deviation. RBC, red blood cell count; WBC, white blood cell count; Hb, hemoglobin; MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; PLT, platelet count; HCT, hematocrit; MCV, mean corpuscular volume; ALT, alanine aminotransferase; CK, creatine kinase; CH, cholesterol; AST, aspartate aminotransferase; ALB, albumin; TP, total plasma protein; BUN, urea nitrogen in blood; and TG, triglycerides. Significant differences as compared with control by Duncan's t-test after ANOVA test (*p < 0.05; **p < 0.01).