Table 3 Hematological values, clinical biochemical findings, and organ weights in SD rats after weekly injection of rhArg1-peg_{5,000 mw} for 4 weeks.

Hematological values

RBC (× 10¹²/l)

8.25 ± 0.87

8.91 ± 0.90

8.20 ± 0.89

WBC (× 10⁹/l)

5.27 ± 1.14

5.68 ± 1.08

4.02 ± 0.71*

Hb (g/l)

136.33 ± 17.25

134.50 ± 6.83

122.33 ± 6.80

MCH (pg)

16.50 ± 1.05

15.23 ± 1.67

15.00 ± 1.12*

MCHC (g/l)

342.00 ± 13.31

287.17 ± 35.82**

305.17 ± 19.26**

PLT (× 10⁹/l)

742.50 ± 156.23

663.00 ± 121.51

545.83 ± 113.26*

HCT (%)

0.399 ± 0.05

0.474 ± 0.06*

0.403 ± 0.039

MCV (fl)

48.33 ± 2.25

53.18 ± 4.03*

49.17 ± 0.96

Clinical biochemical findings

ALT (nmol/l)

818.50 ± 69.16

796.83 ± 110.52

733.48 ± 118.66

CK (μmol/l)

112.60 ± 37.41

88.30 ± 27.17

88.14 ± 24.33

CH (mmol/l)

3.219 ± 0.51

2.500 ± 0.6**

2.879 ± 0.639

AST (nmol/l)

2883.90 ± 602.99

2622.20 ± 420.55

2300.46 ± 512.72

ALB (g/l)

42.60 ± 8.38

40.10 ± 18.83

35.86 ± 5.46

TP (g/l)

86.70 ± 12.49

76.20 ± 10.25

84.86 ± 15.08

BUN (mmol/l)

7.919 ± 3.267

9.305 ± 1.200

9.801 ± 0.815

TG (mmol/l)

3.129 ± 1.087

2.672 ± 1.175

2.832 ± 0.112

Organ weights (g)

Brain

0.380 ± 0.063

0.345 ± 0.050

0.324 ± 0.031*

Gland

0.071 ± 0.026

0.080 ± 0.037

0.074 ± 0.023

Heart

0.184 ± 0.021

0.180 ± 0.031

0.195 ± 0.020

Lung

0.237 ± 0.040

0.216 ± 0.051

0.233 ± 0.038