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Figure 3 | Cancer Cell International

Figure 3

From: The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cells

Figure 3

NSC676914A differentially affects NF-κB transcriptional activity. (A) NF-κB activity following 18 h treatment with varying concentrations of NSC676914 and IKKβ inhibitor, during stimulation of OVCAR3 cells with TNFα (A) and HEK293 cells with TPA (B), as described. NF-κB activity following 18 h treatment with varying concentrations of NSC676914A or IKKβ inhibitor, during stimulation of OVCAR3 cells (C) and HEK293 cells (D) with 1 μM LPA, 1 μg/ml LPS, 10nM TPA and 10 ng/ml TNFα as described. Significant differences in treated OVCAR3 activity were compared between cells with each stimulant and no inhibitors present, as indicated. * p < 0.01, **p < 0.001, ***p < 0.0001.

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