Figure 4From: The small molecule NSC676914A is cytotoxic and differentially affects NFκB signaling in ovarian cancer cells and HEK293 cellsNSC676914A cytotoxicity is rescued by ROS inhibitor. Cell death in parental HEK293 and OVCAR3 cells after 3 days of exposure to NSC676914A or IKKβ inhibitor. Viability of HEK293 cells (A) or OVCAR3 cells (B) and TNFα-treated OVCAR3 (C) cells, after 72 h exposure to NSC676914A or IKKβ inhibitor, following 1 h pretreatment with cell death inhibitors ZVAD 10 μM, NEC-1 20 μM, NAC 1 mM, as described in Methods. Data are average of three independent measurements.Back to article page