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Figure 4 | Cancer Cell International

Figure 4

From: Treatment of human hepatocellular carcinoma by the oncolytic herpes simplex virus G47delta

Figure 4

Treatment of s.c. SMMC-7721 and BEL-7404 tumors with G47Δ. The tumor size was measured by Vernier calipers, and the tumor volume was calculated (V = a × b2/2). The animals were sacrificed if they seemed moribund or the maximal diameter of their tumors exceeded 18 mM, and that day was recorded as the date of death for the survival analysis. G47Δ significantly delayed tumor progression compared with mock treatment. The tumors of 5 SMMC-7721 and 4 BEL-7404 mice in the treated groups regressed completely. A, The mean tumor volumes in the virus-treated and mock-treated SMMC-7721 groups at different times. B and C, The growth of individual tumors in the mock and virus treated SMMC-7721 groups. D, The median survival time for the mice with s.c. SMMC-7721 tumors was increased from 27.5 days for the mock-treated animals to over 82 days for the G47Δ-treated animals. E, The mean tumor volumes in the virus-treated and mock-treated BEL-7404 groups at different times. F and G. The growth of individual tumors in the mock and virus treated BEL-7404 groups. H, The median survival time for the mice with s.c. BEL-7404 tumors was increased from 21 days for the mock-treated animals to over 75 days for the G47Δ-treated animals.

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