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Table 3 Differential gene expression in DLBCL patients before and after chemotherapy

From: Changes of T-lymphocyte subpopulation and differential expression pattern of the T-bet and GATA-3 genes in diffuse large B-cell lymphoma patients after chemotherapy

  EGR-1 T-bet GATA-3 TGF-β
  ΔΔCt1 2-ΔΔCt ΔΔCt1 2-ΔΔCt ΔΔCt1 2-ΔΔCt ΔΔCt2 2-ΔΔCt
Before chemotherapy −1.427 ± 0.565 2.67 ± 1.48 −3.236 ± 1.667 9.43 ± 2.14 −4.388 ± 0.839 20.83 ± 9.05 1.001 ± 0.943 2.01 ± 0.51
After three cycles of chemotherapy 1.117 ± 0.644 0.44 ± 0.23 −0.987 ± 0.606 1.98 ± 1.10 −2.517 ± 0.796 5.71 ± 1.62 0.314 ± 0.268 1.24 ± 0.57
p 0.001* 0.002* 0.028* 0.095
  1. Note: ΔΔCt1 = ΔCt target gene in control-ΔCt target gene in patients, 2-ΔΔCt1 indicates the fold decrease in the expression of target genes in patients compared to controls. ΔΔCt2 = ΔCt TGF-β in patient-ΔCt TGF-β in control, 2-ΔΔCt2 indicates the fold increase in TGF-β expression in patients compared to controls. *indicates that there is significant difference between two groups.