Figure 6
From: In vitro assessment of antitumor activities of the PI3K/mTOR inhibitor GSK2126458
Ovarian serous carcinoma. (a - f) Histology and expression of caspase-3 by immunoperoxidase in treated and untreated tumor specimens. (a - b and c - d) There is preserved tumor histology in the treated tumor compared to untreated tumor, H&E, 10 and 40×. (c and f) stained similar in both tumors with a low level of expression, immunoperoxidase (IP, 40×). (g - h) HPLC runs of intracellular caspase-3 activity in treated and untreated tumor (AMC peak retention time, ~4.8 min).