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Table 1 Clinicopathological features of the studied tumors

From: In vitro assessment of antitumor activities of the PI3K/mTOR inhibitor GSK2126458

Tumor Tumor features & outcome Tumor response to the GSK2126458 treatment
Morphology Caspase-3 activity Immunohistochemistry
Caspase-3 Cytochrome C Annexin A2
I - Invasive ductal carcinoma, NOS; grade 3; CS IIB; size 4.5 cm + + (↑15.7 fold) + (10% → 20%) ¶ (2+ → 2+) ¶ (3+ → 2+)
- ER+, PR-, Her2-neu+, Ki-67 = 70%
- k c = 0.17 μM O2 min-1 mg-1
- Age 73 yr; alive at 2 yr with lung and lymph nodes metastases
II - Invasive ductal carcinoma, NOS, NH grade 2; CS IIB; size 4.5 cm - + (↑3.6 fold) + (1% → 3%) + (2+ → 3+) ¶ (2+ → 2+)
- ER+, PR+, Her2-neu-, Ki-67 = 5%
- k c = 0.15 μMO2 min-1 mg-1
- Age 58 yr; free of disease at 18 months
III - Invasive lobular carcinoma, NOS; NH grade 3; and lobular carcinoma in situ (60% of the tumor mass; the studied component); CS IIIA; size 6.0 cm + - - (1% → 1%) ¶ (3+ → 3+) ± (!) (2+ → 3+)
- ER+, PR+, Her2-neu-, Ki-67 = 30%
- k c = 0.22 μMO2 min-1 mg-1
- Age 62 yr; free of disease at 18 months
IV - Invasive ductal carcinoma, NOS; NH grade 2; CS IIB; size 2.3 cm + - + (1% → 2%) + (2+ → 3+) + (2+ → 3+)
- ER+, PR+, Her2-neu-, Ki-67 = 20%
- k c = 0.06 μMO2 min-1 mg-1
- Age 41 yr; free of disease at 18 month
V - Ovarian dysgerminoma; CS 1A; size 5.0 cm + nd - ǂ (3+ → ?) ǂ (2+ → ?)
- k c = nd
- Age 22 yr; free of disease at 18 months
VI - Ovarian serous carcinoma; CS IIIB - - - (1% → 1%) ¶ (3+ → 3+) ¶ (2+ → 2+)
- k c = nd
- Age 49 yr; free of disease at 12 months
VII - Moderately differentiated adenocarcinoma, colorectal origin; CS IV - - - (5% → 0%) - (1+ → 1+) (↑Necrosis) ¶ (2+ → 2+)
- k c = nd
- Age 60 yr; lost to follow-up
VIII - Poorly differentiated signet ring adenocarcinoma of gastric origin, metastatic to the ovary; CS IV - + + (2% → 4%) ¶ (3+ → 3+) + (2+ → 3+)
- k c = nd
- Age 66 yr; advanced disease on palliative care
  1. NOS, Not otherwise specified; ER, Estrogen receptor; PR, Progesterone receptor; k c , rate of cellular respiration; CS, clinical stage; NH grade, Nottingham histological grade; nd, not done due to insufficient tumor sample; ¶, highly positive staining in treated and untreated specimens; !, inconsistent result (Additional file 2); ǂ, highly positive staining in untreated specimen (treated specimen was lost). Values in parentheses reflect treatment-associated changes in the expression intensity.