Association between genetic polymorphisms in AURKA (rs2273535 and rs1047972) and breast cancer risk: a meta-analysis involving 37,221 subjects

Table 1 Characteristics of the studies included in the meta-analysis

First author	Year	Country	Ethnicity	Design	Genotyping medthod	Number(case/control)	SNP	HWE
Ruan [13]	2011	China	Asian	PB	TaqMan	1334/1568	rs2273535	0.76
Shi [14]	2011	Sweden	Caucasian	PB	TaqMan	763/1516	rs2273535	0.23
MARIE-GENICA [15]	2010	German	Caucasian	PB	MALDI-TOF	3137/5469	rs2273535	0.12
MARIE-GENICA [15]	2010	German	Caucasian	PB	MALDI-TOF	3137/5469	rs1047972	0.17
Couch [16]	2007	CIMBA	Mixed	PB	TaqMan	3884/3303	rs2273535	NA
Tchatchou [17]	2007	German	Caucasian	PB	TaqMan	727/819	rs2273535	0.60
Vidarsdottir [18]	2007	Iceland	Caucasian	NA	PCR-RFLP	759/653	rs2273535	0.07
Cox [19]	2006	USA	Caucasian	NA	TaqMan	1259/1742	rs2273535	0.31
Cox [19]	2006	USA	Caucasian	NA	TaqMan	1259/1742	rs1047972	0.70
Fletcher [20]	2006	UK	Caucasian	PB	PCR-RFLP	507/875	rs2273535	0.13
Ewart-Toland [21]	2005	USA	Mixed	PB	SnAPSHOT	898/448	rs2273535	0.81
Lo [22]	2005	China(Taiwan)	Asian	HB	TaqMan	709/1972	rs2273535	0.23
Lo [22]	2005	China(Taiwan)	Asian	HB	TaqMan	709/1972	rs1047972	0.80
Dai [23]	2004	China	Asian	PB	TaqMan	1102/1188	rs2273535	0.07
Dai [23]	2004	China	Asian	PB	TaqMan	1102/1188	rs1047972	0.68
Egan [24]	2004	USA	Caucasian	PB	Sequencing	941/830	rs2273535	0.31
Egan [24]	2004	USA	Caucasian	PB	Sequencing	941/830	rs1047972	0.68
Sun [25]	2004	China	Asian	HB	PCR-RFLP	520/520	rs2273535	0.11

HWE: Hardy-Weinberg equilibrium; PB: population based; HB: hospital-based; NA: not available; PCR: polymerase chain reaction; RFLP: restriction fragment length polymorphism; MALDI-TOF MS: Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry; CIMBA: the Consortium of Investigators of Modifiers of BRCA1/2 including 16 clinic and population-based research studies and multicenter consortia.