Association between genetic polymorphisms in AURKA (rs2273535 and rs1047972) and breast cancer risk: a meta-analysis involving 37,221 subjects

Table 2 AURKA polymorphisms genotype distribution and allele frequency in cases and controls

First author	Genotype (N)								Allele frequency (N)				MAF (Case/Control)
	Case				Control				Case		Control
	Total	AA	Aa	aa	Total	AA	Aa	aa	A	a	A	a
rs2273535 (T > A)
Ruan 2011	1334	599	568	167	1568	716	691	161	1766	902	2123	1013	0.34/0.32
Shi 2011	763	27	222	514	1516	71	478	967	276	1250	620	2412	0.82/0.80
MARIE-GENICA 2010	3076	1873	1096	107	5466	3290	1927	249	4842	1310	8507	2425	0.21/0.22
Couch 2007	3884	3696		188	3303	3128		175	-	-	-	-	-
Tchatchou 2007	727	37	257	433	819	47	287	485	331	1123	381	1257	0.77/0.77
Vidarsdottir 2007	759	429	288	42	653	401	231	21	1146	372	1033	273	0.25/0.21
Cox 2006	1241	774	401	66	1711	1075	571	65	1949	533	2721	701	0.22/0.21
Fletcher 2006	507	335	154	18	875	547	280	48	824	190	1374	376	0.19/0.22
Ewart-Toland 2005	898	533	303	62	448	279	148	21	1369	427	706	190	0.24/0.21
Lo 2005	707	71	288	348	1969	196	887	886	430	984	1279	2659	0.70/0.68
Dai 2004	1102	121	491	490	1186	149	503	534	733	1471	801	1571	0.67/0.66
Egan 2004	940	559	331	50	830	516	283	31	1449	431	1315	345	0.23/0.21
Sun 2004	520	50	214	256	520	66	262	192	314	726	394	646	0.70/0.62
rs1047972 (G > A)
MARIE-GENICA 2010	3139	2220	850	69	5469	3737	1561	171	5290	988	9035	1903	0.16/0.17
Cox 2006	1240	870	342	28	1724	1215	462	47	2082	398	2892	556	0.16/0.16
Lo 2005	704	543	146	15	1950	1506	414	30	1232	176	3426	474	0.13/0.12
Dai 2004	1102	805	281	16	1188	908	263	17	1891	313	2079	297	0.14/0.13
Egan 2004	905	637	245	23	788	542	225	21	1519	291	1309	267	0.16/0.17

A represents the major allele, a represents the minor allele. MAF: minor allele frequencies.

ISSN: 1475-2867