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Table 3 Meta-analysis results

From: Association between genetic polymorphisms in AURKA (rs2273535 and rs1047972) and breast cancer risk: a meta-analysis involving 37,221 subjects

Comparisons OR 95%CI Pvalue Heterogeneity Effects model
I2 Pvalue
a vs A
rs2273535 1.08 1.01-1.15 0.02 62% 0.002 R
Caucasian 1.05 0.96-1.14 0.31 63% 0.01 R
Asian 1.12 1.00-1.26 0.04 66% 0.03 R
rs1047972 0.98 0.89-1.08 0.75 55% 0.06 R
Caucasian 0.92 0.86-0.98 0.01 0% 0.38 F
Asian 1.10 0.97-1.25 0.14 0% 0.37 F
aa vs AA
rs2273535 1.36 1.06-1.73 <0.00001 82% <0.00001 R
Caucasian 1.32 0.85-2.03 0.21 88% <0.00001 R
Asian 1.22 1.06-1.41 0.007 24% 0.27 F
rs1047972 0.81 0.66-0.99 0.04 22% 0.28 F
Caucasian 0.74 0.59-0.93 0.009 0% 0.56 F
Asian 1.22 0.77-1.95 0.40 0% 0.57 F
Aa vs AA
rs2273535 1.02 0.96-1.08 0.52 0% 0.83 F
Caucasian 1.02 0.95-1.09 0.64 0% 0.67 F
Asian 1.02 0.90-1.14 0.80 0% 0.49 F
rs1047972 0.98 0.91-1.05 0.51 41% 0.14 F
Caucasian 0.94 0.87-1.02 0.15 0% 0.46 F
Asian 1.10 0.95-1.26 0.20 51% 0.15 F
Aa + aa vs AA
rs2273535 1.04 0.98-1.09 0.20 12% 0.33 F
Caucasian 1.02 0.95-1.08 0.61 31% 0.19 F
Asian 1.07 0.96-1.20 0.21 0% 0.48 F
rs1047972 0.99 0.89-1.10 0.84 51% 0.09 R
Caucasian 0.92 0.86-1.00 0.04 0% 0.40 F
Asian 1.10 0.96-1.27 0.16 33% 0.22 F
aa vs AA + Aa
rs2273535 1.15 1.01-1.31 0.04 69% 0.0001 R
Caucasian 1.13 0.92-1.38 0.24 66% 0.007 R
Asian 1.23 1.10-1.50 0.05 76% 0.006 R
rs1047972 0.82 0.67-1.00 0.05 14% 0.33 F
Caucasian 0.75 0.60-0.94 0.01 0% 0.60 F
Asian 1.20 0.75-1.91 0.44 0% 0.50 F
  1. A: represents the major allele, a: represents the minor allele, F: fixed effects model, R: random effects model.
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