Table 1 Array CGH was performed to determine chromosomal changes in the DCIS cell lines

1

ABL1

-

-

-

-

-

-

9q34.1

2

ABL2

-

-

-

-

-

-

1q24-q25

3

ALPK2

-

-

-

Loss(1)

-

-

18q21.31q

4

APC

-

Gain(3)

Gain(3)

-

-

Gain(3)

5q21-q22

5

ATM

-

-

-

-

-

-

11q22.3

6

BCR

-

-

-

-

-

-

22q11.21

7

BMPR1A

-

-

-

-

-

-

10q22.3

8

BRAF

-

-

-

-

-

-

7q34

9

BRCA1

-

-

CNLOH

-

CNLOH

CNLOH

17q21

10

BRCA2

-

-

-

-

-

-

13q12.3

11

CDK4

-

-

-

-

-

-

12q14

12

CDKN2A

-

-

-

-

-

-

9p21

13

CHEK2

-

-

-

-

-

-

22q12.1

14

CREBBP

-

-

-

-

-

Gain(3)

16p13.3

15

CTNNB1

-

-

-

-

-

-

3p21

16

CTNNBIP1

-

-

-

-

-

-

1pter-p36.31

17

EGFR

-

-

-

-

-

-

7p12

18

EIF4E

-

-

-

-

-

-

4q21-q21

19

EP300

-

-

-

-

-

-

22q13

20

ERBB2

-

-

CNLOH

-

-

CNLOH

17q21.1

21

ETV6

-

-

-

-

-

-

12q13

22

FGFR1

CNLOH

CNLOH

CNLOH

CNLOH

-

CNLOH

8p11.2-p11.1

23

FGFR2

-

-

-

-

-

-

10q26

24

FGFR3

-

-

-

-

-

-

4p16.3

25

FHIT

-

-

-

-

-

-

3p14.2

26

FLT3

-

-

-

-

-

-

13q12

27

HRAS

-

-

-

-

-

-

11p15.5

28

KIT

-

-

-

-

-

-

4q11-q12

29

KRAS2

-

-

-

-

-

-

12p12.1

30

MAP2K4

-

Loss(1)/LOH

CNLOH

-

CNLOH

CNLOH

17p11.2

31

MAPK11

-

-

-

-

-

-

22q13.33

32

MAPK12

-

-

-

-

-

-

22q13.3

33

MAPK13

-

-

-

-

-

-

6p21

34

MAPK14

-

-

-

-

-

-

6p21.3-p21.2

35

MET

-

-

-

-

-

-

7q31

36

MLL

-

-

-

-

-

-

11q23

37

MTOR

-

-

-

-

-

-

1p36

38

MYC

-

-

-

-

-

-

8q24.12-q24.13

39

MYST3

-

-

-

-

-

-

8p11

40

NRAS

-

-

-

-

-

-

1p13.2

41

NTRK1

-

-

-

-

-

CNLOH

14q21-q22

42

NTRK3

-

-

-

-

-

-

15q24-q25

43

PAX8

-

Loss(1)

-

Loss9(1)

-

-

2q12-q14

44

PDGFRA

-

-

-

-

-

-

4q12

45

PIK3C2G

-

-

-

-

-

-

12p12

46

PIK3CA

-

-

-

-

-

-

3q26.3

47

PIP

-

-

-

-

-

-

7q34

48

PPARG

-

-

-

-

-

-

3p25

49

PRCC

-

-

-

-

-

CNLOH

1q21.1

50

PRKA1A

-

-

CNLOH

CNLOH

CNLOH

17q23-q24

51

PRKCB

-

-

-

-

-

Gain(3)

16p12

52

PTEN

-

-

-

-

-

-

10q23.3

53

RB1

-

-

-

-

-

-

13q14.2

54

RET

-

-

-

-

-

-

10q11.2

55

SMAD4

-

-

-

-

-

-

18q21.1

56

SCGB2A2

-

-

-

-

-

-

11q13

57

SCGB2A1

-

-

-

-

-

-

11q13

58

STK11

-

-

-

-

-

-

19p13.3

59

TCF4

-

-

-

-

-

-

18q21.1

60

TERT

-

Gain(3)

Gain(3)

-

-

Gain(3)

5p15.33

61

TFF1

-

-

-

-

-

-

21q22.3

62

TP53

Loss(1)

Loss(1)/LOH

CNLOH

-

Loss(1)/LOH

CNLOH

17p13.1

63

VHL

-

-

-

-

-

-

3p25.3

64

WWOX

-

-

-

-

-

-

16q23.3-q24.1