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Table 1 Incidences of MSI-L, MSI-H, and LOH in blood samples in patients and reference groups from the three sampling events

From: Chemotherapy induced microsatellite instability and loss of heterozygosity in chromosomes 2, 5, 10, and 17 in solid tumor patients

Group

No. of samples

No. of MSI- L

No. of MSI-H

No. of LOH

Patients

    

Pre-treatment

117

0

0

0

Post-treatment 1

117

51

27

48

Post-treatment 2

117

30

0

48

Reference (healthy)

    

Pre-treatment

60

0

0

0

Post-treatment 1

60

2

0

0

Post-treatment 2

60

0

0

0

  1. LOH at alleles 109 and 118 of APC was accompanied by the appearance of a novel allele of 162 base pairs (see Additional file 1: Figure S1). Furthermore, the incidence rate versus age correlation showed that the incidence of MSI/LOH increased with age (see Additional file 2: Figure S2). Cancer-specific incidences of instability showed that pancreatic, lung, and gastric cancer patients had high incidences of MSI (Table 4).