Group | No. of samples | No. of MSI- L | No. of MSI-H | No. of LOH |
---|
Patients
| Â | Â | Â | Â |
Pre-treatment | 117 | 0 | 0 | 0 |
Post-treatment 1 | 117 | 51 | 27 | 48 |
Post-treatment 2 | 117 | 30 | 0 | 48 |
Reference (healthy)
| Â | Â | Â | Â |
Pre-treatment | 60 | 0 | 0 | 0 |
Post-treatment 1 | 60 | 2 | 0 | 0 |
Post-treatment 2 | 60 | 0 | 0 | 0 |
- LOH at alleles 109 and 118 of APC was accompanied by the appearance of a novel allele of 162 base pairs (see Additional file 1: Figure S1). Furthermore, the incidence rate versus age correlation showed that the incidence of MSI/LOH increased with age (see Additional file 2: Figure S2). Cancer-specific incidences of instability showed that pancreatic, lung, and gastric cancer patients had high incidences of MSI (Table 4).