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Figure 4 | Cancer Cell International

Figure 4

From: Nucleofection optimization and in vitro anti-tumourigenic effect of TRAIL-expressing human adipose-derived mesenchymal stromal cells

Figure 4

The anti-proliferative effects of ADMSCs-TRAIL on haematological malignancies as analyzed by MTS assay. FACS analysis of TRAIL receptors revealed that only R2 (DR5) expression was high in both K562 and REH lines, whereas lower expression of all four receptors was seen in KMS-28BM (A). ADMSCs-TRAIL and its conditioned medium (80% and 100% ) induced significant inhibition of REH proliferation, whereas both K562 and KMS-28BM remained resistant to TRAIL-mediated inhibition (B). Increased ratio of ADMSCs-TRAIL and malignant lines induced significant cellular proliferation noticed in REH and KMS-28BM (C; *p < 0.01, **p < 0.001; t-test).

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