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Table 1 Characteristics of included studies of gastric cancer and GSTM1 status

From: Glutathione S-transferase gene GSTM1, gene-gene interaction, and gastric cancer susceptibility: evidence from an updated meta-analysis

Study Ethnicity (region) No. of cases/controls GC diagnosis Source of control selection Matching criteria Genotyping method Exposures Null GSTM1 n(%)
Case Control
Richard C. Strange 1991 [13] Caucasian (Britain) 19/49 Histologically confirmed Clinic based NA Horizontal starch gel electrophoresis NA 14(73.7) 20(40.8)
Shoji Harada 1992 [14] Asian (Japan) 19/84 NA Healthy volunteers NA PCR NA 14(73.7) 40(47.6)
Shunji Kato 1996 [15] Asian (Japan) 64/120 Histologically confirmed Clinic based Age,gender PCR-RFLP NA 30(46.9) 61(50.8)
Takahiko Katoh 1996 [16] Asian (Japan) 139/126 Histologically confirmed Healthy volunteers Age Multiplex PCR Smoking status 79(56.8) 55(43.6)
Mark Deakin 1996 [17] Caucasian (Britain) 136/577 NA Clinic based NA PCR NA 72(52.9) 316(54.8)
Liakhovich VV 1997 [18] Caucasian (Russia) 49/53 NA Healthy volunteers NA PCR NA 21(42.9) 21(39.6)
Enders K. W. Ng 1998 [19] Asian (China) 35/35 NA Clinic based Age,gender Differential PCR Helicobacter pylori infection 23(65.7) 13(52.0)
Gisela Martins 1998 [20] Caucasian (Portugal) 148/84 Histologically diagnosis Healthy volunteers NA Differential PCR NA 71(48.0) 44(52.0)
Veronica Wendy Setiawan 2000 [21] Asian (China) 87/419 Pathologically diagnosis Population based Geographical origin PCR Smoking status, alcohol drinking and Helicobacter pylori infection 42(48.3) 212(50.6)
Qing Lan 2001 [22] Caucasian (Poland) 347/426 NA Population based Age,gender PCR-RFLP NA 167(48.1) 222(52.1)
Lin Cai 2001 [23] Asian (China) 95/94 Histologically or operation diagnosis Population based Age,gender PCR Smoking status and GSTT1 genotyping 60(63.2) 43(45.7)
Iraj Saadat 2001 [24] Caucasian (Iran) 42/131 Pathologically diagnosis Healthy volunteers Age,gender PCR GSTT1 genotyping 26(61.9) 53(40.5)
Alessandro Sgambato 2002 [25] Caucasian (Italy) 8/100 NA Healthy volunteers NA PCR NA 5(62.5) 53(53.0)
Ming-Shiang Wu 2002 [26] Asian (China) 356/278 Histologically diagnosis Healthy volunteers NA Multiplex PCR NA 173(48.6) 136(48.9)
Chang-Ming Gao 2002 [27] Asian (China) 153/223 Histopathologically diagnosis Population based Age,gender Multiplex PCR Smoking status 90(58.8) 133(59.6)
Suck Chei Choi 2003 [28] Asian (South Korea) 80/177 Pathologically diagnosis Healthy volunteers NA PCR NA 46(57.5) 95(53.7)
Jucimara Colombo1 2004 [29] Caucasian (Brazil) 87/135 Histopathologically diagnosis Healthy volunteers Age,gender Multiplex PCR NA 45(51.7) 60(44.4)
Jucimara Colombo2 2004 [29] Negroid (Brazil) 13/15 Histopathologically diagnosis Healthy volunteers Age,gender Multiplex PCR NA 2(15.4) 2(13.3)
Mark J. Roth 2004 [30] Asian (China) 90/454 Pathologically, radiologically, cytological or operation diagnosis Healthy cohort subjects Age,gender RT-PCR NA 66(73.3) 145(31.9)
Shioto Suzuki 2004 [31] Asian (Japan) 145/177 NA Clinic based Age PCR NA 87(60.0) 84(47.5)
Auxiliadora González 2004 [32] Caucasian (Costa Rica) 31/51 Pathologically diagnosis Healthy volunteers NA Multiplex PCR NA 15(48.4) 26(51.0)
María M. Torres 2004 [33] Caucasia (Colombia) 46/96 Pathologically diagnosis Healthy volunteers Age,gender Multiplex PCR NA 30(65.2) 36(37.5)
Jing Shen 2005 [34] Asian (China) 112/675 Endoscopic and pathological diagnosis Healthy volunteers NA PCR Smoking status 71(63.4) 361(53.5)
Kuang-Chi Lai 2005 [35] Asian (China) 123/121 Histologically or operation diagnosis Healthy volunteers NA Multiplex PCR NA 73(59.3) 55(45.5)
Hao Li 2005 [36] Asian (China) 100/62 Pathologically diagnosis Clinic based NA PCR Smoking status and Helicobacter pylori infection 67(67.0) 26(41.9)
Li-Na Mu 2005 [37] Asian (China) 196/393 Pathologically diagnosis Population based Age,gender PCR NA 127(64.8) 235(59.8)
Hong-Mei Nan 2005 [38] Asian (South Korea) 400/614 Histologically diagnosis Clinic based Age,gender Multiplex PCR NA 251(62.8) 360(58.6)
Lulufer Tamer 2005 [39] Caucasian (Turkey) 70/204 Histologically or operation diagnosis Population based NA RT-PCR Smoking status and GSTT1 genotyping 40(57.1) 88(43.1)
Antonio Agudo 2006 [40] Caucasian (Britain) 242/932 Pathologically diagnosis Healthy cohort subjects Age, gender, center and date of blood collection PCR Smoking status 122(50.4) 498(53.4)
Kuen Lee 2006 [41] Caucasian (Chile) 73/263 Histologically diagnosis Clinic based NA PCR Smoking status and alcohol drinking 13(17.8) 56(21.3)
Carmen Martinez 2006 [42] Caucasian (Spain) 87/329 Histologically diagnosis Healthy volunteers Geographical origin Multiplex PCR GSTT1 genotyping 33(37.9) 149(45.3)
Su Hyung Hong 2006 [43] Asian (South Korea) 108/238 Histologically diagnosis Healthy volunteers NA Multiplex PCR Smoking status and alcohol drinking and Helicobacter pylori infection 60(55.6) 134(56.3)
Stefania Boccia 2007 [44] Caucasian (Italy) 107/254 Histologically diagnosis Clinic based Age,gender Multiplex PCR Smoking status and alcohol drinking 59(56.2) 135(52.7)
Annamaria Ruzzo 2007 [45] Caucasian (Italy) 79/112 Pathologically diagnosis Population based Age,gender Multiplex PCR Helicobacter pylori infection and GSTT1 genotyping 35(44.3) 61(54.5)
Louise Wideroff 2007 [46] Caucasian (America) 116/208 Histologically diagnosis Population based Age,gender PCR NA 61(52.6) 121(58.2)
Shweta Tripathi 2008 [47] Caucasian (India) 76/100 Histopathologically diagnosis Clinic based Age,gender PCR GSTT1 genotyping 31(40.8) 39(39.0)
Mansour S. Al-Moundhri 2009 [48] Caucasian (Oman) 107/107 NA Healthy volunteers Geographical origin Multiplex PCR Helicobacter pylori infection and GSTT1 genotyping 42(39.3) 32(30.0)
Mohammad Masoudi 2009 [49] Caucasian (Iran) 67/134 Pathologically diagnosis Healthy volunteers Age,gender PCR NA 37(55.2) 60(44.8)
Manzoor A. Malik 2009 [50] Caucasian (India) 108/195 Histopathologically diagnosis Healthy volunteers Age Multiplex PCR Smoking status 64(59.3) 79(40.5)
Kristin A. Moy 2009 [51] Asian (China) 170/735 Histopathologically, clinically, radiologically or operation diagnosis Healthy cohort subjects Age and date of biospecimen collection TaqMan GSTT1 genotyping 98(57.6) 415(56.5)
Kazem Zendehdel 2009 [52] Caucasian (Sweden) 124/469 NA Population based Age,gender Multiplex PCR Smoking status 70(56.5) 239(51.0)
Jin-Mei Piao 2009 [53] Asian (South Korea) 2213/1699 Histologically diagnosis Healthy volunteers NA TaqMan GSTT1 genotyping 1225(55.4) 923(54.3)
Thai V. Nguyen 2010 [54] Asian (Vietnam) 59/109 NA Clinic based NA PCR NA 43(73.0) 75(69.0)
Domenico Palli 2010 [55] Caucasian (Italy) 296/546 Histologically diagnosis Population based NA Multiplex PCR GSTT1 genotyping 166(56.1) 275(50.4)
Dhirendra Singh Yadav 2010 [56] Caucasian (India) 133/270 Histopathologically diagnosis Healthy volunteers Age,gender Multiplex PCR NA 49(37.0) 120(44.0)
Mohamad Darazy 2011 [57] Caucasian (Lebanon) 13/70 Histologically diagnosis Healthy volunteers Age,gender PCR NA 6(46.2) 12(17.1)
Ya-ping Luo 2011 [58] Asian (China) 123/129 Pathologically diagnosis Healthy volunteers NA PCR NA 93(75.6) 71(55.0)
An-Ping Zhang 2011 [59] Asian (China) 194/412 Histologically diagnosis Healthy volunteers NA PCR-CTPP GSTT1 genotyping 105(54.1) 194(47.1)
Deepmala Yadav 2011 [60] Caucasian (India) 41/130 Pathologically diagnosis Healthy volunteers Geographical origin Multiplex PCR GSTT1 genotyping 11(26.8) 38(29.2)
Mª Asunción García-González 2012 [61] Caucasian (Spain) 557/557 Histopathologically diagnosis Clinic based Age,gender Multiplex PCR Helicobacter pylori infection and GSTT1 genotyping 283(50.8) 267(47.9)
Chen Jing 2012 [62] Asian (China) 410/410 Histologically diagnosis Healthy volunteers Age,gender PCR-CTPP GSTT1 genotyping 240(58.6) 207(50.6)
Mridul Malakar 2012 [63] Caucasian (India) 102/204 Histopathologically diagnosis Population based Age,gender PCR Smoking status and GSTT1 genotyping 57(55.9) 97(47.5)
Aptullah Haholu 2013 [64] Caucasian (Turkey) 50/57 Pathologically diagnosis Population based Age,gender Multiplex PCR NA 26(52.0) 25(43.9)
Sang-Yong Eom 2013 [65] Asian (South Korea) 477/476 Histologically diagnosis Healthy volunteers Age,gender Multiplex PCR NA 263(55.1) 259(54.4)
  1. GC, gastric cancer; NA: relative data not available in original studies; PCR: Polymerase chain reaction; PCR–RFLP: Polymerase chain reaction-restriction fragment length polymorphism; RT-PCR: Real-Time PCR; PCR-CTPP: Polymerase chain reaction with confronting two -pair primers.