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Table 2 Summary of pooled odds ratios (OR) with confidence intervals (CI) of the GSTM1 polymorphism and gastric cancer risk

From: Glutathione S-transferase gene GSTM1, gene-gene interaction, and gastric cancer susceptibility: evidence from an updated meta-analysis

Group of analysis

n†

GSTM1 (Null vs. Present*)

M#

Heterogeneity

OR (95% CI)

POR

I2(%)

PQ※

  Overall

54

1.207(1.106-1.317)

<0.001

R

49.9

<0.001

Ethnicity

  Asians

24

1.264(1.164-1.422)

<0.001

R

51.8

0.002

  Caucasians

29

1.154(1.008-1.321)

0.037

R

50.6

0.001

  Negroids

1

1.182(0.142-9.827)

0.887

F

—¶

—¶

Smoking status

  Non-smokers

14

1.370(1.043-1.800)

0.024

R

46.7

0.028

  Ever-smokers

14

1.558(1.111-2.183)

0.010

R

69.6

<0.001

Alcohol drinking

  Non-drinkers

4

0.872(0.623-1.220)

0.425

F

0.0

0.757

  Ever-drinkers

4

1.112(0.771-1.602)

0.570

F

0.0

0.905

Helicobacter pylori infection

  Helicobacter pylori negative

7

0.869(0.654-1.156)

0.334

F

6.8

0.373

  Helicobacter pylori positive

7

1.595(1.104-2.304)

0.013

R

49.9

0.076

  1. †Number of studies included.
  2. *The genetic comparison model for GSTM1–GSTT1interaction analysis is Dual null genotype vs. Non-null genotype.
  3. # M, model of meta-analysis; R, random-effects model; F, fixed-effects model.
  4. ※ PQ: P values of Q-test for heterogeneity test.
  5. ¶Values could not be calculated out.