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Table 2 Summary of pooled odds ratios (OR) with confidence intervals (CI) of the GSTM1 polymorphism and gastric cancer risk

From: Glutathione S-transferase gene GSTM1, gene-gene interaction, and gastric cancer susceptibility: evidence from an updated meta-analysis

Group of analysis n GSTM1 (Null vs. Present*) M# Heterogeneity
OR (95% CI) POR I2(%) PQ
  Overall 54 1.207(1.106-1.317) <0.001 R 49.9 <0.001
Ethnicity
  Asians 24 1.264(1.164-1.422) <0.001 R 51.8 0.002
  Caucasians 29 1.154(1.008-1.321) 0.037 R 50.6 0.001
  Negroids 1 1.182(0.142-9.827) 0.887 F
Smoking status
  Non-smokers 14 1.370(1.043-1.800) 0.024 R 46.7 0.028
  Ever-smokers 14 1.558(1.111-2.183) 0.010 R 69.6 <0.001
Alcohol drinking
  Non-drinkers 4 0.872(0.623-1.220) 0.425 F 0.0 0.757
  Ever-drinkers 4 1.112(0.771-1.602) 0.570 F 0.0 0.905
Helicobacter pylori infection
  Helicobacter pylori negative 7 0.869(0.654-1.156) 0.334 F 6.8 0.373
  Helicobacter pylori positive 7 1.595(1.104-2.304) 0.013 R 49.9 0.076
  1. †Number of studies included.
  2. *The genetic comparison model for GSTM1–GSTT1interaction analysis is Dual null genotype vs. Non-null genotype.
  3. # M, model of meta-analysis; R, random-effects model; F, fixed-effects model.
  4. PQ: P values of Q-test for heterogeneity test.
  5. Values could not be calculated out.