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Table 1 Associations of miR-196a and/or miR-196b expression with the clinicopathological characteristics of colorectal cancer

From: Upregulation of microRNA-196a and microRNA-196b cooperatively correlate with aggressive progression and unfavorable prognosis in patients with colorectal cancer

Clinical features Case number (%) miR-196a-high miR-196b-high miR-196a-high/miR-196b-high
(N, %) P (N, %) P (N, %) P
Gender        
Male 76 (60.32) 46 (60.53) NS 48 (63.16) NS 31 (40.79) NS
Female 50 (39.68) 30 (60.00) 30 (60.00) 21 (42.00)
Age (years)        
<66 48 (30.10) 28 (58.33) NS 28 (58.33) NS 21 (43.75) NS
≥66 78 (69.90) 48 (61.54) 50 (64.10) 31 (39.74)
Site of primary tumor        
Right-sided 48 (38.10) 30 (62.50) NS 30 (62.50) NS 20 (41.67) NS
Left-sided 46 (36.51) 28 (60.87) 28 (60.87) 20 (43.48)
Rectum 32 (25.40) 18 (56.25) 20 (62.50) 12 (37.50)
Tumor size (cm)        
<5 70 (55.56) 40 (57.14) NS 42 (60.00) NS 30 (42.86) NS
≥5 56 (44.44) 36 (64.29) 36 (64.29) 22 (39.29)
Depth of tumor invasion        
T1-T2 47 (37.30) 26 (55.32) NS 28 (59.57) NS 20 (42.55) NS
T3-T4 79 (62.70) 50 (63.29) 50 (63.29) 32 (40.51)
Lymph node metastasis        
Negative 68 (53.97) 24 (35.29) 0.01 26 (38.24) 0.01 12 (17.65) 0.008
Positive 58 (46.03) 52 (89.66) 52 (89.66) 40 (68.97)
TNM stage        
I 13 (10.32) 0 (0) 0.006 0 (0) 0.006 0 (0) <0.001
II 46 (36.51) 20 (43.48) 22 (47.83) 10 (18.87)
III 50 (39.68) 39 (78.00) 39 (78.00) 25 (50.00)
IV 17 (13.49) 17 (100.00) 17 (100.00) 17 (100.00)
Histological grade        
Well/moderately 80 (63.49) 40 (50.00) 0.02 40 (50.00) 0.02 22 (27.50) 0.01
Poorly 46 (36.51) 36 (78.26) 38 (82.61) 30 (65.22)
  1. Note: ‘NS’ refers to the difference without statistical significance.