Table 1 Associations of miR-196a and/or miR-196b expression with the clinicopathological characteristics of colorectal cancer
Clinical features | Case number (%) | miR-196a-high | miR-196b-high | miR-196a-high/miR-196b-high | |||
|---|---|---|---|---|---|---|---|
(N, %) | P | (N, %) | P | (N, %) | P | ||
Gender | |||||||
Male | 76 (60.32) | 46 (60.53) | NS | 48 (63.16) | NS | 31 (40.79) | NS |
Female | 50 (39.68) | 30 (60.00) | 30 (60.00) | 21 (42.00) | |||
Age (years) | |||||||
<66 | 48 (30.10) | 28 (58.33) | NS | 28 (58.33) | NS | 21 (43.75) | NS |
≥66 | 78 (69.90) | 48 (61.54) | 50 (64.10) | 31 (39.74) | |||
Site of primary tumor | |||||||
Right-sided | 48 (38.10) | 30 (62.50) | NS | 30 (62.50) | NS | 20 (41.67) | NS |
Left-sided | 46 (36.51) | 28 (60.87) | 28 (60.87) | 20 (43.48) | |||
Rectum | 32 (25.40) | 18 (56.25) | 20 (62.50) | 12 (37.50) | |||
Tumor size (cm) | |||||||
<5 | 70 (55.56) | 40 (57.14) | NS | 42 (60.00) | NS | 30 (42.86) | NS |
≥5 | 56 (44.44) | 36 (64.29) | 36 (64.29) | 22 (39.29) | |||
Depth of tumor invasion | |||||||
T1-T2 | 47 (37.30) | 26 (55.32) | NS | 28 (59.57) | NS | 20 (42.55) | NS |
T3-T4 | 79 (62.70) | 50 (63.29) | 50 (63.29) | 32 (40.51) | |||
Lymph node metastasis | |||||||
Negative | 68 (53.97) | 24 (35.29) | 0.01 | 26 (38.24) | 0.01 | 12 (17.65) | 0.008 |
Positive | 58 (46.03) | 52 (89.66) | 52 (89.66) | 40 (68.97) | |||
TNM stage | |||||||
I | 13 (10.32) | 0 (0) | 0.006 | 0 (0) | 0.006 | 0 (0) | <0.001 |
II | 46 (36.51) | 20 (43.48) | 22 (47.83) | 10 (18.87) | |||
III | 50 (39.68) | 39 (78.00) | 39 (78.00) | 25 (50.00) | |||
IV | 17 (13.49) | 17 (100.00) | 17 (100.00) | 17 (100.00) | |||
Histological grade | |||||||
Well/moderately | 80 (63.49) | 40 (50.00) | 0.02 | 40 (50.00) | 0.02 | 22 (27.50) | 0.01 |
Poorly | 46 (36.51) | 36 (78.26) | 38 (82.61) | 30 (65.22) | |||