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Figure 3 | Cancer Cell International

Figure 3

From: CDK2-AP1 inhibits growth of breast cancer cells by regulating cell cycle and increasing docetaxel sensitivity in vivo and in vitro

Figure 3

CDK2-AP1 was knocked down in MCF-7 cells and overexpressed in SK-BR-3 cells. A, CDK2-AP1 siRNA was transfected into MCF-7 cells and CDK2-AP1 overexpressed lentivirus vector was transfected into SK-BR-3 cells. B, CDK2-AP1 RNAi lentivirus infection results in 80.1% reduction of CDK2-AP1 mRNA in RNA interfered MCF-7. C, CDK2-AP1 mRNA is upregulated 4.3-fold in CDK2-AP1 overexpressed SK-BR-3 cells compared to the control cells. D, CDK2-AP1 protein level is reduced by 77.7% in interfected MCF-7 cells. E, CDK2-AP1 protein expression increases 4 fold in overexpressed SK-BR-3.

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