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Figure 4 | Cancer Cell International

Figure 4

From: CDK2-AP1 inhibits growth of breast cancer cells by regulating cell cycle and increasing docetaxel sensitivity in vivo and in vitro

Figure 4

CDK2-AP1 acts as a growth suppressor of breast cancer cells by arresting cells in G0/G1 and G2/M phase. Docetaxel sensitivity is increased in breast cancer cells in the case of CDK2-AP1 expression. A, after CDK2-AP1 has been knockdown in MCF7 cells, viability was increases by 1.31 fold compared with the control group. B, CDK2-AP1 overexpression suppresses the growth of SK-BR-3 cells. C, colony number of MCF7 cells transfected with the CDK2-AP1 RNAi lentivirus is twice that of the control group, whereas for SK-BR-3 cells overexpressing CDK2-AP1 it is reduced. D, overexpressed CDK2-AP1 arrests SK-BR-3 cells in G0/G1 and G2/M phase, whereas downregulated CDK2-AP1 promotes MCF-7 cells into S phase.

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Cancer Cell International

ISSN: 1475-2867

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