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Figure 5 | Cancer Cell International

Figure 5

From: CDK2-AP1 inhibits growth of breast cancer cells by regulating cell cycle and increasing docetaxel sensitivity in vivo and in vitro

Figure 5

Loss of CDK2-AP1 promotes tumorigenesis of MCF-7 cells in nude mice, inhibits tumor apoptosis, and lowers sensitivity to docetaxel. A, inhibition of CDK2-AP1 results in a significant increase in tumor size (p < 0.05). B, tumor volumes increase compared to the controls (p < 0.05). C, expression of CDK2/ cyclinD1 and the ratio of bcl2/ bax both increase after inhibition of CDK2-AP1 according to the result of IHC. D, CDK2-AP1 silenced MCF-7, MCF-7 and CDK2-AP1 overexpressed SK-BR-3 cells have been used in the drug sensitivity experiments, docetaxel sensitivity was increased in the case of CDK2-AP1 expression, whereas silencing CDK2-AP1 induces resistance to treatment in breast cancer (p < 0.05). Expression of CDK2-AP1 had little influence on epirubicin sensitivity.

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Cancer Cell International

ISSN: 1475-2867

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