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Table 3 Meta-analysis of EGF +61A/G polymorphism and gastric cancer risk

From: EGF +61A/G polymorphism contributes to increased gastric cancer risk: evidence from a meta-analysis

Analysis

No. of studies

GG vs. AA (Homozygote)

AG vs. AA (Heterozygote)

GG + AG vs. AA (Dominant model)

GG vs. AG + AA (Recessive model)

OR (95% CI)

P/P Q

OR (95% CI)

P/P Q

OR (95% CI)

P/P Q

OR (95% CI)

P/P Q

Overall

6

1.438(1.021-2.025)

0.038/0.074

1.193(0.963-1.478)

0.106/0.927

1.256(1.025-1.539)

0.028/0.468

1.265(1.002-1.596)

0.048/0.020

Ethnicity

         

 Asian

5

1.658(1.265-2.173)

0.000/0.834

1.269(0.964-1.670)

0.090/0.924

1.473(1.134-1.914)

0.004/0.928

1.355(1.174-1.564)

0.000/0.318

 Caucasian

1

0.769(0.498-1.189)

0.238/—

1.083(0.769-1.526)

0.647/—

0.977(0.707-1.349)

0.886/—

0.733(0.500-1.073)

0.110/—

Source of control

         

 HB

4

1.486(0.835-2.647)

0.178/0.023

1.156(0.885-1.510)

0.286/0.901

1.196(0.929-1.538)

0.164/0.272

1.328(0.882-2.000)

0.174/0.006

 PB

2

1.477(1.035-2.108)

0.031/0.836

1.262(0.882-1.806)

0.204/0.415

1.377(0.976-1.942)

0.068/0.616

1.220(1.016-1.466)

0.033/0.357

Study quality

         

 High

3

1.552(1.140-2.112)

0.005/0.847

1.272(0.931-1.738)

0.131/0.714

1.421(1.055-1.915)

0.021/0.825

1.267(1.077-1.491)

0.004/0.450

 Low

3

1.425(0.659-3.081)

0.368/0.021

1.127(0.839-1.512)

0.427/0.813

1.126(0.853-1.487)

0.403/0.232

1.294(0.714-2.344)

0.396/0.003

HWE

         

 Yes

5

1.658(1.265-2.173)

0.000/0.834

1.269(0.964-1.670)

0.090/0.924

1.473(1.134-1.914)

0.004/0.928

1.355(1.174-1.564)

0.000/0.318

 No

1

0.769(0.498-1.189)

0.238/—

1.083(0.769-1.526)

0.647/—

0.977(0.707-1.349)

0.886/—

0.733(0.500-1.073)

0.110/—

Tumor location

         

 Cardia

3

1.322(1.041-1.987)

0.013/0.632

1.198(0.946-1.973)

0.238/0.322

1.356(1.013-1.966)

0.017/0.390

1.156(1.025-2.491)

0.022/0.374

 Non-cardia

2

1.253(1.019-3.294)

0.028/0.388

1.159(0.847-1.869)

0.389/0.476

1.137(0.753-2.697)

0.528/0.387

1.297(1.009-2.984)

0.046/0.454

Histological type

         

 Intestinal

2

1.316(1.013-2.231)

0.016/0.671

1.065(0.789-1.842)

0.357/0.412

1.201(1.083-1.978)

0.013/0.721

1.092(0.992-2.257)

0.054/0.357

 Diffuse

2

1.240(1.072-3.013)

0.022/0.336

1.103(0.817-1.627)

0.465/0.511

1.212(0.971-1.845)

0.066/0.348

1.115(1.008-2.327)

0.041/0.303

  1. EGF, epidermal growth factor; P Q , P values of Q-test for heterogeneity test; OR, odds ratio; CI, confidence intervals; HB, Hospital–based studies; PB, Population-based studies; HWE, Hardy–Weinberg equilibrium in control population.