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Table 3 Meta-analysis of EGF +61A/G polymorphism and gastric cancer risk

From: EGF +61A/G polymorphism contributes to increased gastric cancer risk: evidence from a meta-analysis

Analysis No. of studies GG vs. AA (Homozygote) AG vs. AA (Heterozygote) GG + AG vs. AA (Dominant model) GG vs. AG + AA (Recessive model)
OR (95% CI) P/P Q OR (95% CI) P/P Q OR (95% CI) P/P Q OR (95% CI) P/P Q
Overall 6 1.438(1.021-2.025) 0.038/0.074 1.193(0.963-1.478) 0.106/0.927 1.256(1.025-1.539) 0.028/0.468 1.265(1.002-1.596) 0.048/0.020
Ethnicity          
 Asian 5 1.658(1.265-2.173) 0.000/0.834 1.269(0.964-1.670) 0.090/0.924 1.473(1.134-1.914) 0.004/0.928 1.355(1.174-1.564) 0.000/0.318
 Caucasian 1 0.769(0.498-1.189) 0.238/— 1.083(0.769-1.526) 0.647/— 0.977(0.707-1.349) 0.886/— 0.733(0.500-1.073) 0.110/—
Source of control          
 HB 4 1.486(0.835-2.647) 0.178/0.023 1.156(0.885-1.510) 0.286/0.901 1.196(0.929-1.538) 0.164/0.272 1.328(0.882-2.000) 0.174/0.006
 PB 2 1.477(1.035-2.108) 0.031/0.836 1.262(0.882-1.806) 0.204/0.415 1.377(0.976-1.942) 0.068/0.616 1.220(1.016-1.466) 0.033/0.357
Study quality          
 High 3 1.552(1.140-2.112) 0.005/0.847 1.272(0.931-1.738) 0.131/0.714 1.421(1.055-1.915) 0.021/0.825 1.267(1.077-1.491) 0.004/0.450
 Low 3 1.425(0.659-3.081) 0.368/0.021 1.127(0.839-1.512) 0.427/0.813 1.126(0.853-1.487) 0.403/0.232 1.294(0.714-2.344) 0.396/0.003
HWE          
 Yes 5 1.658(1.265-2.173) 0.000/0.834 1.269(0.964-1.670) 0.090/0.924 1.473(1.134-1.914) 0.004/0.928 1.355(1.174-1.564) 0.000/0.318
 No 1 0.769(0.498-1.189) 0.238/— 1.083(0.769-1.526) 0.647/— 0.977(0.707-1.349) 0.886/— 0.733(0.500-1.073) 0.110/—
Tumor location          
 Cardia 3 1.322(1.041-1.987) 0.013/0.632 1.198(0.946-1.973) 0.238/0.322 1.356(1.013-1.966) 0.017/0.390 1.156(1.025-2.491) 0.022/0.374
 Non-cardia 2 1.253(1.019-3.294) 0.028/0.388 1.159(0.847-1.869) 0.389/0.476 1.137(0.753-2.697) 0.528/0.387 1.297(1.009-2.984) 0.046/0.454
Histological type          
 Intestinal 2 1.316(1.013-2.231) 0.016/0.671 1.065(0.789-1.842) 0.357/0.412 1.201(1.083-1.978) 0.013/0.721 1.092(0.992-2.257) 0.054/0.357
 Diffuse 2 1.240(1.072-3.013) 0.022/0.336 1.103(0.817-1.627) 0.465/0.511 1.212(0.971-1.845) 0.066/0.348 1.115(1.008-2.327) 0.041/0.303
  1. EGF, epidermal growth factor; P Q , P values of Q-test for heterogeneity test; OR, odds ratio; CI, confidence intervals; HB, Hospital–based studies; PB, Population-based studies; HWE, Hardy–Weinberg equilibrium in control population.