From: EGF +61A/G polymorphism contributes to increased gastric cancer risk: evidence from a meta-analysis
Analysis | No. of studies | GG vs. AA (Homozygote) | AG vs. AA (Heterozygote) | GG + AG vs. AA (Dominant model) | GG vs. AG + AA (Recessive model) | ||||
---|---|---|---|---|---|---|---|---|---|
OR (95% CI) | P/P Q | OR (95% CI) | P/P Q | OR (95% CI) | P/P Q | OR (95% CI) | P/P Q | ||
Overall | 6 | 1.438(1.021-2.025) | 0.038/0.074 | 1.193(0.963-1.478) | 0.106/0.927 | 1.256(1.025-1.539) | 0.028/0.468 | 1.265(1.002-1.596) | 0.048/0.020 |
Ethnicity | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Asian | 5 | 1.658(1.265-2.173) | 0.000/0.834 | 1.269(0.964-1.670) | 0.090/0.924 | 1.473(1.134-1.914) | 0.004/0.928 | 1.355(1.174-1.564) | 0.000/0.318 |
 Caucasian | 1 | 0.769(0.498-1.189) | 0.238/— | 1.083(0.769-1.526) | 0.647/— | 0.977(0.707-1.349) | 0.886/— | 0.733(0.500-1.073) | 0.110/— |
Source of control | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 HB | 4 | 1.486(0.835-2.647) | 0.178/0.023 | 1.156(0.885-1.510) | 0.286/0.901 | 1.196(0.929-1.538) | 0.164/0.272 | 1.328(0.882-2.000) | 0.174/0.006 |
 PB | 2 | 1.477(1.035-2.108) | 0.031/0.836 | 1.262(0.882-1.806) | 0.204/0.415 | 1.377(0.976-1.942) | 0.068/0.616 | 1.220(1.016-1.466) | 0.033/0.357 |
Study quality | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 High | 3 | 1.552(1.140-2.112) | 0.005/0.847 | 1.272(0.931-1.738) | 0.131/0.714 | 1.421(1.055-1.915) | 0.021/0.825 | 1.267(1.077-1.491) | 0.004/0.450 |
 Low | 3 | 1.425(0.659-3.081) | 0.368/0.021 | 1.127(0.839-1.512) | 0.427/0.813 | 1.126(0.853-1.487) | 0.403/0.232 | 1.294(0.714-2.344) | 0.396/0.003 |
HWE | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Yes | 5 | 1.658(1.265-2.173) | 0.000/0.834 | 1.269(0.964-1.670) | 0.090/0.924 | 1.473(1.134-1.914) | 0.004/0.928 | 1.355(1.174-1.564) | 0.000/0.318 |
 No | 1 | 0.769(0.498-1.189) | 0.238/— | 1.083(0.769-1.526) | 0.647/— | 0.977(0.707-1.349) | 0.886/— | 0.733(0.500-1.073) | 0.110/— |
Tumor location | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Cardia | 3 | 1.322(1.041-1.987) | 0.013/0.632 | 1.198(0.946-1.973) | 0.238/0.322 | 1.356(1.013-1.966) | 0.017/0.390 | 1.156(1.025-2.491) | 0.022/0.374 |
 Non-cardia | 2 | 1.253(1.019-3.294) | 0.028/0.388 | 1.159(0.847-1.869) | 0.389/0.476 | 1.137(0.753-2.697) | 0.528/0.387 | 1.297(1.009-2.984) | 0.046/0.454 |
Histological type | Â | Â | Â | Â | Â | Â | Â | Â | Â |
 Intestinal | 2 | 1.316(1.013-2.231) | 0.016/0.671 | 1.065(0.789-1.842) | 0.357/0.412 | 1.201(1.083-1.978) | 0.013/0.721 | 1.092(0.992-2.257) | 0.054/0.357 |
 Diffuse | 2 | 1.240(1.072-3.013) | 0.022/0.336 | 1.103(0.817-1.627) | 0.465/0.511 | 1.212(0.971-1.845) | 0.066/0.348 | 1.115(1.008-2.327) | 0.041/0.303 |